Results 1 to 10 of about 2,203 (171)

Mechanisms of Pilocarpine‐Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle [PDF]

FASEB BioAdvances
Pilocarpine, a muscarinic receptor agonist, is clinically used to reduce intraocular pressure via ciliary muscle contraction. However, the intracellular signaling pathways mediating pilocarpine‐induced nitric oxide (NO) and prostaglandin E2 (PGE2 ...
Giovanna Benozzi, Emmanuel Quinteros Villarruel, Andrés F. Zuluaga, Betina Orman   +3 more
doaj   +3 more sources

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathyResearch in context [PDF]

EBioMedicine
Summary: Background: There is no effective definitive treatment for diabetic peripheral neuropathy (DPN). Strategies that target nerve pathology, limit nerve degeneration, and promote axon regeneration can potentially be beneficial.
Ajith Sivadasan, Paul Fernyhough, Nigel A. Calcutt, Katie E. Frizzi, Kimberly Gardner, Angela Hansen, Ari Breiner, Douglas W. Zochodne, Natalia McInnes, Zubin Punthakee, Sylvie Gosselin, Bruce A. Perkins, Vera Bril   +12 more
doaj   +2 more sources

Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond [PDF]

Parasitology
Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does not act ...
Weisi Wang, Jun Li, Wenjing Qi, Ying Chen, Mengxiao Tian, Chuanchuan Wu, Yao Zhang, Yingfang Yu, Shuai Han, Xiumin Han, Liping Duan, Wenbao Zhang   +11 more
doaj   +2 more sources

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in App^NL-G-F KI mice. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Tsuda Y, Madokoro Y, Suzuki K, Ooba T, Sato T, Uchida Y, Nagai-Arakawa I, Saito T, Hara H, Hida H, Matsukawa N.   +10 more
europepmc   +2 more sources

Pirenzepine exhibits anti-prostate cancer activity and enhances checkpoint inhibitor-based immunotherapy by targeting STING [PDF]

European Journal of Medical Research
Purpose Therapeutic options targeting programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for use in human malignancies, showing clinical benefits.
Jinge Xu, Junyu Li, Junwen Zhang, Yongsheng Yu   +3 more
doaj   +2 more sources

Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala [PDF]

Frontiers in Cellular Neuroscience
The basolateral amygdala (BLA) plays a crucial role in context-specific learning and memory by integrating valence-specific stimuli with internal physiological states.
Todd J. Sahagian, Scott W. Harden, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Charles J. Frazier, Charles J. Frazier   +7 more
doaj   +2 more sources

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]

Pigment Cell Melanoma Res
Schematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Guo MS, Wu Q, Xia Y, Wu J, Wang X, Yuen GKW, Dong TT, Gao J, Tsim KWK.   +8 more
europepmc   +2 more sources

GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation [PDF]

Scientific Reports
Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development.
Yun He, Qin Ni, Cuiyun Zhang, liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu   +6 more
doaj   +2 more sources

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
In Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +2 more sources

Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]

BMC Chemistry
In the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang   +5 more
doaj   +2 more sources