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PLASMA AND BILIARY DISPOSITION OF PIRENZEPINE IN MAN

open access: yesClinical and Experimental Pharmacology and Physiology, 1986
SUMMARY1. The binding of pirenzepine, a selective muscarinic receptor antagonist to plasma and bile, was studied in vitro and in vivo. Plasma and hepatic bile were incubated with 14C‐pirenzepine and the bound fraction of 14C‐pirenzepine determined by equilibrium dialysis. The bound fractions were 12.6% (s.e.m.
Lee, SP, Paxton, JW, Choong, YS
openaire   +5 more sources
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Pirenzepine in Erosive Duodenitis

Scandinavian Journal of Gastroenterology, 1985
M Guslandi, A Tittobello
exaly   +2 more sources

Pyrimidobenzodiazepines. Synthesis of pirenzepine analog.

Die Pharmazie, 1990
The synthesis of Pyrimido[4,5-b][1,5]benzodiazepine derivatives from 4-(o-aminophenylene)amino-5-ethoxy-carbonyl-1,2-dihydro-6-methyl-2 - oxopyrimidine has been described. Pyrimidobenzodiazepine 5 alkylated with N-methyl-N'-chloroacetyl-piperazine gives a product related to pirenzepine. Compound 5 shows weak antianxiety and antidepressive action.
Długosz, Anna, Machoń, Zdzisław
openaire   +2 more sources

Pirenzepine and Gastrointestinal Motility: Differential Effect of Pirenzepine in the Gut

1985
The capacity of pirenzepine to reduce gastric acid secretion in the basal state and after various forms of stimulation is well established by now (Jaup 1981). It is still under discussion whether the ulcer-healing and symptom-relieving effect of pirenzepine is solely due to the moderate acid reduction observed or whether other pharmacological ...
R. W. Stockbrügger   +3 more
openaire   +1 more source

Central oxotremorine antagonist properties of pirenzepine

Life Sciences, 1988
Pirenzepine, the prototype M1 muscarinic receptor antagonist, is an important compound for investigating the functional significance of M1 receptors at the integrated level of behavior but may have limitations imposed by its physical chemistry. Like the nonselective antagonist methylatropine, pirenzepine is highly hydrophilic and crosses the blood ...
J M, Witkin   +3 more
openaire   +2 more sources

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