Results 1 to 10 of about 2,163 (132)

Mechanisms of Pilocarpine-Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle. [PDF]

FASEB Bioadv
Pilocarpine activates M1 and M3 muscarinic receptors in porcine ciliary muscle, engaging calcium‐dependent phospholipase C (PLC), nitric oxide synthase (NOS), and cyclooxygenase (COX) pathways that increase prostaglandin E2 (PGE2) synthesis. Beyond nitric oxide (NO) modulation, PGE2 emerges as a key mediator linking muscarinic signaling to ciliary ...
Benozzi G, Quinteros Villarruel E, Zuluaga AF, Orman B.   +3 more
europepmc   +2 more sources

Comparison of pirenzepine, ranitidine, and pirenzepine-ranitidine combination for reducing preoperative gastric fluid acidity and volume in children

British Journal of Anaesthesia, 1998
We conducted a two-part controlled study to evaluate the efficacy of preoperative oral pirenzepine (muscarinic receptor antagonist known to inhibit gastric secretion), ranitidine, and the combination pirenzepine-ranitidine in controlling gastric fluid pH and volume in 210 ASA I children, aged 2-14 yr, undergoing elective surgery.
N, Maekawa, K, Nishina, K, Mikawa, M, Shiga, H, Obara   +4 more
openaire   +2 more sources

Pirenzepin [PDF]

, 2020
openaire   +1 more source

Use of Clinical Pharmacology in Slowing the Myopia Epidemic. [PDF]

Clin Pharmacol Ther
Novack GD.
europepmc   +1 more source

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy. [PDF]

EBioMedicine
Sivadasan A, Fernyhough P, Calcutt NA, Frizzi KE, Gardner K, Hansen A, Breiner A, Zochodne DW, McInnes N, Punthakee Z, Gosselin S, Perkins BA, Bril V.   +12 more
europepmc   +1 more source

The Induction of Long-Term Potentiation by Medial Septum Activation under Urethane Anesthesia Can Alter Gene Expression in the Hippocampus. [PDF]

Int J Mol Sci, 2023
Dobryakova YV, Gerasimov K, Spivak YS, Korotkova T, Koryagina A, Deryabina A, Markevich VA, Bolshakov AP.   +7 more
europepmc   +1 more source

Pharmacological Characterization of Vasomotor Responses in the Tree Shrew (<i>Tupaia belangeri</i>) Basilar Artery: A Promising Model for Human Cerebrovascular Research. [PDF]

Biology (Basel)
Islam MZ, Kayesh MEH, Kohara M, Tsukiyama-Kohara K, Miyamoto A.   +4 more
europepmc   +1 more source

Blood disorders associated with pirenzepine. [PDF]

BMJ, 1986
B H, Stricker, R H, Meyboom, P A, Bleeker, K, van Wieringen   +3 more
openaire   +2 more sources

Modern Methods for Preventing the Progression of Myopia in Children. [PDF]

J Clin Med
Pniakowska Z, Czarkowska S, Kurys N, Orłowska M, Jurowski P.   +4 more
europepmc   +1 more source

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy. [PDF]

Int J Mol Sci
Chauhan S, Calcutt NA, Fernyhough P.
europepmc   +1 more source