Results 11 to 20 of about 2,203 (171)
Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis [PDF]
PharmaceuticalsPyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Sara Abdalfattah +7 more
doaj +2 more sources
Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]
AnimalsGravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam +6 more
doaj +2 more sources
Translating Basic Science to Clinical Applications: A Narrative Review of Repurposed Pharmacological Agents in Preclinical Models of Diabetic Neuropathy [PDF]
BiomedicinesDiabetic neuropathy (DN) remains a major clinical burden, characterized by progressive sensory dysfunction, pain, and impaired quality of life. Despite the available symptomatic treatments, there is a pressing need for disease-modifying therapies.
Corina Andrei +3 more
doaj +2 more sources
Frontiers in Neurology, 2021 HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment.
May Madi Han +5 more
doaj +1 more source
Insects, 2022 Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopolamine,
Chaïma Messikh +2 more
doaj +1 more source
Unexpected scaffold rearrangement product of pirenzepine found in commercial samples
Scientific Reports, 2021 Pharmacovigilance aims at a better understanding of the molecular events triggered by medications to prevent adverse effects, which despite significant advances in our analytical repertoire plague the use of drugs until today. In this study, we find that
Marius Ozenil +10 more
doaj +1 more source
Scientific Reports, 2022 Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year.
Oksana A. Lenina, Konstantin A. Petrov
doaj +1 more source
Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park +3 more
doaj +1 more source
ESC Heart Failure, Volume 10, Issue 6, Page 3311-3329, December 2023., 2023 Abstract Aims We aim to explore the role and mechanism of vagus nerve stimulation (VNS) in coronary endothelial cells and angiogenesis in infarcted hearts. Methods and results Seven days after rat myocardial infarction (MI) was prepared by ligation of the left anterior descending coronary artery, the left cervical vagus nerve was treated with ...
Yan Wang +14 more
wiley +1 more source
Clozapine for the treatment of aggressiveness and agitation in advanced dementia
Psychogeriatrics, Volume 23, Issue 6, Page 963-972, November 2023., 2023 Abstract Background Distressing behavioural symptoms, particularly agitation and aggressiveness, remain a difficult problem in everyday clinical practice in the treatment of multimorbid patients with dementia. Clozapine may be an effective therapeutic alternative in this context.
Arwed E. Michael +3 more
wiley +1 more source