Results 41 to 50 of about 5,030 (261)
Journal of Pharmacological Sciences, 2015 The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH).
Tomonori Yamanishi +5 more
doaj +1 more source
Cholinergic-mediated IP3-ereceptor activation induces long-lasting synaptic enhancement in CA1 pyramidal neurons [PDF]
, 2008 Cholinergic–glutamatergic interactions influence forms of synaptic plasticity that are thought to mediate memory and learning. We tested in vitro the induction of long-lasting synaptic enhancement at Schaffer collaterals by acetylcholine (ACh) at the ...
Borde, M. +4 more
core +1 more source
BMC Neuroscience, 2012 Background Cholinergic transmission has been implicated in learning, memory and cognition. However, the cellular effects induced by muscarinic acetylcholine receptors (mAChRs) activation are poorly understood in the neocortex. We investigated the effects
Gigout Sylvain +5 more
doaj +1 more source
Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]
, 2011 Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago +3 more
core +1 more source
Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]
, 2006 Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Abogadie, FC, Allen, TGJ, Brown, DA
core +1 more source
Advances in Pharmacological Sciences, 2009 In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg +2 more
doaj +1 more source
Are we doing enough for the patient with myopia? A literature review
British and Irish Orthoptic Journal, 2011 Aim: Myopia is one of the most common eye conditions and often has a progressive nature. With higher degrees come greater risks of visual disability; however, typically no treatment is offered clinically to tackle myopic progression. This review aims to
Marina Parker, Anna R. O’connor
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt +4 more
doaj +1 more source
Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]
, 2015 Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa +3 more
core +1 more source
Methods of preventing and retarding the progression of myopia
Journal of Education, Health and Sport, 2019 Myopia is an increasing problem worldwide. Its prevalence is predicted to over 4 billion of people in 2050, what would be almost 50% of the population.
Ewa Grudzińska +2 more
doaj +3 more sources