Results 51 to 60 of about 2,203 (171)

Effects of cholecystokinin-octapeptide and cerulein on ovine digestive motility under cholinergic blockade

European Journal of Biological Research, 2017
In sheep, contribution of cholinergic system to the control of gastrointestinal motility by cholecystokinin is unknown. Accordingly, in six non-fasted rams chronic experiments were conducted and the myoelectrical activity of abomasal antrum, duodenum and
Krzysztof W. Romański
doaj  

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

Frontiers in Cellular Neuroscience, 2019
The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing
Viktoriya Morozova, Viktoriya Morozova, Leah S. Cohen, Ali El-Hadi Makki, Alison Shur, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Abdeslem El Idrissi, Alejandra D. Alonso, Alejandra D. Alonso   +10 more
doaj   +1 more source

Neural Influences on Tumor Progression Within the Central Nervous System

CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.
Neurons can establish connections with tumor cells via chemical or electrical synapses, regulating the progression of tumors in the central nervous system. In addition, they can also enhance tumor proliferation and the formation of neurogliomal synapses by secreting proteins into the tumor microenvironment through paracrine signaling.
Wenhao Lv, Yongjie Wang
wiley   +1 more source

Autoantibodies against Submandibular Gland Muscarinic Cholinoceptor Subtypes in Primary Sjögren Syndrome

European Journal of Inflammation, 2005
Sjögren Syndrome (SS) is a chronic autoimmune disease characterized by parasympathetic exocrine gland dysfunction. Here, the involvement of submandibular gland muscarinic acetylcholine receptor (mAChR) M 4 subtype is proposed as an IgG target together ...
S. Reina, L. Sterin-Borda, B. Orman, E. Borda   +3 more
doaj   +1 more source

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding

Brain Sciences, 2020
Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This study
Sarah S. Ch’ng, Adam J. Walker, Madeleine McCarthy, Thien-Kim Le, Natalie Thomas, Andrew Gibbons, Madhara Udawela, Snezana Kusljic, Brian Dean, Andrea Gogos   +9 more
doaj   +1 more source

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

Journal of Neuroscience Research, Volume 102, Issue 3, March 2024.
Diagram illustrating the innervation of basolateral amygdalar pyramidal projection neurons (PN) and parvalbumin‐expressing interneurons (PV) by cholinergic (ACh) and GABAergic neurons of the basal forebrain, including what is known about the distribution of muscarinic receptors (M1 and M2) expressed by these structures, as well as cortical and thalamic
Alexander Joseph McDonald
wiley   +1 more source

Behavioral effects of Bj-PRO-7a, a proline-rich oligopeptide from Bothrops jararaca venom [PDF]

Brazilian Journal of Medical and Biological Research
The heptapeptide Bj-PRO-7a, isolated and identified from Bothrops jararaca (Bj) venom, produces antihypertensive and other cardiovascular effects that are independent on angiotensin converting enzyme inhibition, possibly relying on cholinergic muscarinic
L.C. Turones, K.R. da Cruz, G. Camargo-Silva, L.L. Reis-Silva, D. Graziani, P.M. Ferreira, P.M. Galdino, G.R. Pedrino, R. Santos, E.A. Costa, D. Ianzer, C.H. Xavier   +11 more
doaj   +2 more sources

Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

Frontiers in Cellular Neuroscience, 2019
Cisplatin remains an indispensable drug for the systemic treatment of many solid tumors. However, a major dose-limiting side-effect is ototoxicity. In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer,
Anke Tropitzsch, Marcus Müller, François Paquet-Durand, Frank Mayer, Hans-Georg Kopp, Andre Schrattenholz, Andrea Müller, Hubert Löwenheim   +7 more
doaj   +1 more source

Effects of AF-DX116 and Other Muscarinic Receptor Antagonists on Orthostatic Hypotension in Autonomic Imbalanced (SART-Stressed) Rats

Journal of Pharmacological Sciences, 2005
SART (specific alternation of rhythm in temperature)-stressed rats are an animal model of autonomic imbalance created by exposing animals to repeated cold stress. The SART-stressed rats have been shown to easily develop orthostatic hypotension (OH).
Taeko Hata, Yoshinori Funakami, Eiji Itoh   +2 more
doaj   +1 more source

The Lower Urinary Tract Science Group Abstracts—ICI‐RS 2024

Neurourology and Urodynamics, Volume 44, Issue 3, Page 691-697, March 2025.
Christopher H. Fry, Andrew Gammie, Bahareh Vahabi, Faezeh A. Hassani, Karen D. McCloskey, Mathijs M. de Rijk, Pradeep Tyagi, Hikaru Hashitani, Michael Winder, Patrik Aronsson, Basu Chakrabarty   +10 more
wiley   +1 more source