Results 71 to 80 of about 2,988 (212)

Muscarinic depolarization of layer II neurons of the parasubiculum. [PDF]

open access: yesPLoS ONE, 2013
The parasubiculum (PaS) is a component of the hippocampal formation that sends its major output to layer II of the entorhinal cortex. The PaS receives strong cholinergic innervation from the basal forebrain that is likely to modulate neuronal ...
Stephen D Glasgow, C Andrew Chapman
doaj   +1 more source

Neural Influences on Tumor Progression Within the Central Nervous System

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.
Neurons can establish connections with tumor cells via chemical or electrical synapses, regulating the progression of tumors in the central nervous system. In addition, they can also enhance tumor proliferation and the formation of neurogliomal synapses by secreting proteins into the tumor microenvironment through paracrine signaling.
Wenhao Lv, Yongjie Wang
wiley   +1 more source

Effects of cholecystokinin-octapeptide and cerulein on ovine digestive motility under cholinergic blockade

open access: yesEuropean Journal of Biological Research, 2017
In sheep, contribution of cholinergic system to the control of gastrointestinal motility by cholecystokinin is unknown. Accordingly, in six non-fasted rams chronic experiments were conducted and the myoelectrical activity of abomasal antrum, duodenum and
Krzysztof W. Romański
doaj  

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

open access: yesFrontiers in Cellular Neuroscience, 2019
The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing
Viktoriya Morozova   +10 more
doaj   +1 more source

Autoantibodies against Submandibular Gland Muscarinic Cholinoceptor Subtypes in Primary Sjögren Syndrome

open access: yesEuropean Journal of Inflammation, 2005
Sjögren Syndrome (SS) is a chronic autoimmune disease characterized by parasympathetic exocrine gland dysfunction. Here, the involvement of submandibular gland muscarinic acetylcholine receptor (mAChR) M 4 subtype is proposed as an IgG target together ...
S. Reina   +3 more
doaj   +1 more source

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

open access: yesJournal of Neuroscience Research, Volume 102, Issue 3, March 2024.
Diagram illustrating the innervation of basolateral amygdalar pyramidal projection neurons (PN) and parvalbumin‐expressing interneurons (PV) by cholinergic (ACh) and GABAergic neurons of the basal forebrain, including what is known about the distribution of muscarinic receptors (M1 and M2) expressed by these structures, as well as cortical and thalamic
Alexander Joseph McDonald
wiley   +1 more source

Lower levels of cortical [3H]pirenzepine binding to postmortem tissue defines a sub-group of older people with schizophrenia with less severe cognitive deficits

open access: yes, 2023
Multiple lines of evidence argue for lower levels of cortical muscarinic M1 receptors (CHRM1) in people with schizophrenia which is possibly due to a sub-group within the disorder who have a marked loss of CHRM1 (muscarinic receptor deficit sub-group ...
Haroutunian, V, Dean, B, Scarr, E
core   +1 more source

A selective antimuscarinic agent: pirenzepine. Review of its pharmacologic and clinical properties

open access: yes, 1989
The heterogeneity of muscarinic receptors has been well supported by differential characteristics between pirenzepine and atropine both in receptor binding and in whole tissue pharmacology studies.
BERNARDINI MC   +3 more
core   +1 more source

Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy

open access: yesFrontiers in Cellular Neuroscience, 2019
Cisplatin remains an indispensable drug for the systemic treatment of many solid tumors. However, a major dose-limiting side-effect is ototoxicity. In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer,
Anke Tropitzsch   +7 more
doaj   +1 more source

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding

open access: yesBrain Sciences, 2020
Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This study
Sarah S. Ch’ng   +9 more
doaj   +1 more source

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