Results 21 to 30 of about 51,828 (245)

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

Metabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai, Xiaohui Dai, Xingang Miao, Bing Xie, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +7 more
doaj   +1 more source

The polarographic determination of chlorpromazine and chlorpromazine sulphoxide

Journal of Pharmacy and Pharmacology, 1966
Abstract Cathodic polarography of solutions containing between 0·1 and 5·0 μg/ml of both chlorpromazine and its sulphoxide enables the sulphoxide to be determined directly. Reductive polarography of the solution after bromination gives an additive wave from which the chlorpromazine is determined by subtraction.
G S, Porter, J, Beresford
openaire   +2 more sources

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Medicina, 2019
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.
Jeand Baloch, M. Sohail, Hafiz Sarwar, M. H. Kiani, G. Khan, S. Jahan, M. Rafay, M. T. Chaudhry, M. Yasinzai, G. Shahnaz   +9 more
semanticscholar   +1 more source

Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

Frontiers in Cardiovascular Medicine, 2021
Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate.
James Jiqi Wang, James Jiqi Wang, Zuowen He, Zuowen He, Yan Yang, Bo Yu, Bo Yu, Hong Wang, Hong Wang, Hu Ding, Hu Ding, Guanglin Cui, Guanglin Cui, Luyun Wang, Luyun Wang, Dao Wen Wang, Dao Wen Wang, Jiangang Jiang, Jiangang Jiang   +18 more
doaj   +1 more source

Pencil graphite electrode as an electrochemical sensor for the voltammetric determination of chlorpromazine

Journal of Science: Advanced Materials and Devices, 2018
A selective, simple and sensitive electrochemical sensor has been developed using pencil leads (pencil graphite electrode, PGE) for the investigation of chlorpromazine (CPZ). The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques
H. Purushothama, Y. A. Nayaka, M. Vinay, P. Manjunatha, R. O. Yathisha, K. V. Basavarajappa   +5 more
semanticscholar   +1 more source

Salivary flow rate and decayed, missing, and filled teeth (DMFT) in female patients with schizophrenia on chlorpromazine therapy

Journal of Dental Sciences, 2013
Background/purpose: The purpose of the study was to investigate relationship between saliva flow rates, estrogen levels, and caries prevalence in female psychiatric patients under antipsychotic therapy.
Jelena Krunić, Nikola Stojanović, Nedeljka Ivković, Dragica Stojić   +3 more
doaj   +1 more source

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Scientific Reports, 2018
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for ...
J. Weeks, W. M. Roberts, Caitlyn Leasure, B. Suzuki, Kristin J. Robinson, Heather N Currey, P. Wangchuk, R. Eichenberger, Aleen D. Saxton, T. Bird, B. Kraemer, A. Loukas, J. Hawdon, C. Caffrey, Nicole F. Liachko   +14 more
semanticscholar   +1 more source

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

OncoTarget, 2017
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and ...
C. Oliva, Wei Zhang, C. Langford, M. Suto, C. Griguer   +4 more
semanticscholar   +1 more source

The Effects of Chlorpromazine on Reproductive System and Function in Female Rats [PDF]

International Journal of Fertility and Sterility, 2015
Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth ...
Zahra Zamani, Samad Zare, Rajabali Sadrkhanlou, Abbas Ahmadi, Elham Movahed   +4 more
doaj   +1 more source

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

Pharmaceutics, 2022
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and ...
Eszter Fliszár-Nyúl, Rita Csepregi, Gábor Benkovics, Lajos Szente, Miklós Poór   +4 more
doaj   +1 more source