Results 31 to 40 of about 28,288 (192)

Propofol vs. Chlorpromazine for Acute Migraine Treatment: Insights from a Prospective Randomized Trial

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi
Objective: This study aimed to compare the efficacy of propofol and chlorpromazine in managing acute migraine attacks and to contribute to optimizing the treatment of patients with migraine in the ED.Methods: This prospective, randomized observational ...
Özlem Güneysel, Sarper Sağlam
doaj   +1 more source

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

Agmatine prevents acute chlorpromazine-induced neurotoxicity in rats [PDF]

Arhiv za farmaciju, 2015
The present study was directed to potentially beneficial effects of agmatine (AGM) on oxidative/nitrosative stress development in selective vulnerable brain regions during chlorpromazine (HPZ) treatment in rats.
Dejanović Bratislav, Ninković Milica, Stojanović Ivana, Lavrnja Irena, Radičević Tatjana, Stevanović Ivana   +5 more
doaj   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Histological evaluation and E-cadherin and β-catenin expression in kidney of dogs submitted to renal ischemia and reperfusion after chlorpromazine administration

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Renal ischemia can be associated with some urological procedures, such as renovascular surgery or kidney transplantation, that are often followed by acute renal failure.
L.B. Menezes, M.C.S. Fioravanti, F.A. Oliveira, M.S.B. Silva, L.G. Franco, T.P. Sales, M.M. Andrascko, L.L.B. Guimarães, M.P. Miguel, E.G. Araújo   +9 more
doaj   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Determination of Chlorpromazine Using Molecular Imprinting Polymers in Different Sample Matrices

Indonesian Journal of Chemistry
Antipsychotic drugs, including chlorpromazine, are frequently used to treat mental illnesses. However, prolonged exposure to even small amounts of the substance can accumulate and cause a potential human health risk.
Eman Wajeh Ammen, Yehya Kamal Al-Bayati
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Effect of chlorpromazine on intact and irradiated aliquot ctdsDNA samples

مجلة كلية الطب, 2007
Bagkground:Chlorpromazine is widely used in human medicine in the therapy of schizophrenia, organic psychosis and the manic phase of manic depressive illness. It expressed a selective cytotoxicity and the results of genotoxicity were positive. Objectives:
Ali M. Abbed, Marwan S.M. Al-Nimer, Mohammad A. ALhamdany   +2 more
doaj