Results 31 to 40 of about 36,001 (235)

Chlorpromazine for psychosis induced aggression or agitation [PDF]

, 2008
Background: Agitated or violent behaviour constitutes 10% of all emergency psychiatric treatment. Some guidelines do not recommend the use of chlorpromazine for rapid tranquillisation but it is still often used for this purpose.
Gul, Muhammad, Muhammad Gul, Uzair Ahmed, Adams, Clive E., Clive E Adams, Ahmed, Uzair   +5 more
core   +1 more source

Chlorpromazine and Memory Consolidation

, 1965
To determine whether chlorpromazine affects learning by disrupting memory traces 40 23-hr. water-deprived rats were given 1 trial per day in a straight alley maze for a water reward.
Henry E. Adams, L. J. Peacock, John F. Glenn   +2 more
core   +1 more source

Observational Study of Chlorpromazine in Hospitalized Patients with Covid-19 Running title: Chlorpromazine in hospitalized patients with Covid-19

, 2021
International audienceIntroduction: Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential antiviral and anti-inflammatory effects.Objective: The aim of this ...
Sanchez-Rico, Marina, Carlos Blanco, Christel Daniel, Vernet, Raphaël, Frédéric Limosin, Hoertel, Nicolas, Paris, Nicolas, Beeker, Nathanael, Guillaume Airagnes, Bellamine, Ali, Limosin, Frederic, Raphaël Vernet, Nicolas Paris, Jannot, Anne-Sophie, Daniel, Christel, Nathanaël Beeker, Guillaume Lemaitre, Anne-Sophie Jannot, Blanco, Carlos, Lemaitre, Guillaume, Ali Bellamine, Bernaux, Mélodie, Alexandre Gramfort, Mélodie Bernaux, Gramfort, Alexandre, Airagnes, Guillaume, Marina Sánchez-Rico, Nicolas Hoertel, Cédric Lemogne, Lemogne, Cédric, Neuraz, Antoine, Antoine Neuraz   +31 more
core   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Renal protective potential of pentoxifylline, chlorpromazine, and lovastatin in ischemia-reperfusion injury: An experimental study.

PLoS ONE
This study aimed to evaluate the ability of pentoxifylline when compared to lovastatin and chlorpromazine as nephroprotective substances in cases of renal ischemia and reperfusion syndrome (IRI).
Daniel Peixoto Pereira, Brunna Silva Moreira, Marcela Aldrovani Rodrigues, Larissa Fernandes Magalhães, Luana de Oliveira Branco, Natani Silva Reis, Sofia Borin-Crivellenti, Leandro Zuccolotto Crivellenti   +7 more
doaj   +1 more source

Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications

Gels
This study investigates the synthesis, characterization, and antimicrobial properties of hydrogels synthesized through the UV-pulsed laser photopolymerization of a polymer–photoinitiator–chlorpromazine mixture.
Tatiana Tozar, Simona Nistorescu, Gratiela Gradisteanu Pircalabioru, Mihai Boni, Angela Staicu   +4 more
doaj   +1 more source

A dual dopaminergic therapy with L-3,4-dihydroxyphenylalanine and chlorpromazine for the treatment of blepharospasm, a focal dystonia: Possible implications for striosomal D1 signaling

Frontiers in Neurology, 2022
Impairment of balanced activity between dopamine D1 and D2 receptor functions in the striatum, particularly in striatal functional subdivisions (i.e., striosome and matrix compartments), has been proposed to underlie dystonia genesis.
Shinichi Matsumoto, Hidetaka Koizumi, Hideki Shimazu, Hideki Shimazu, Ryuji Kaji, Satoshi Goto, Satoshi Goto   +6 more
doaj   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways

Journal of Translational Medicine
Background In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM ...
Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi, Claudia Abbruzzese   +5 more
doaj   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source