Results 51 to 60 of about 36,001 (235)

Effects of agmatine on chlorpromazine-induced neuronal injury in rat [PDF]

, 2018
This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment.
Ninković, Milica, Dejanović, Bratislav, Lavrnja, Irena, Stojanović, Ivana, Vuković-Dejanović, Vesna, Pavlović, Miloš, Begović, Vesna, Mirković, Duško, Stevanović, Ivana, Mirković, Dšsko   +9 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Histological evaluation and E-cadherin and β-catenin expression in kidney of dogs submitted to renal ischemia and reperfusion after chlorpromazine administration

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Renal ischemia can be associated with some urological procedures, such as renovascular surgery or kidney transplantation, that are often followed by acute renal failure.
L.B. Menezes, M.C.S. Fioravanti, F.A. Oliveira, M.S.B. Silva, L.G. Franco, T.P. Sales, M.M. Andrascko, L.L.B. Guimarães, M.P. Miguel, E.G. Araújo   +9 more
doaj   +1 more source

Effects of an Inpatient Program on Medication Errors in Hospitalized People with Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Hospitalized people with Parkinson's disease (PwP) face increased risks of medication errors and discharge to non‐home settings, both of which are associated with adverse outcomes. This study assessed differences in medication error rates and discharge outcomes before and after implementation of a dedicated inpatient program for hospitalized ...
Camila C. Piccinin, Jeryl Ritzi T. Yu, Victoria Stepanyants, Olivia Hogue, Claire Sonneborn, Anne Brooks, Patricia Clark, Shannon Shaffer, Laurie Moser, Tatiana Lopez‐Gonzalez, Brent S. Sokola, Kim Lewin, Roman Popov, Scott A. Sperling, Hubert H. Fernandez, Benjamin L. Walter   +15 more
wiley   +1 more source

Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials

BMC Medicine, 2005
Background Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated.
Borrill Jo, Clarke Mike, Thornley Ben, Rathbone John, Adams Clive, Wahlbeck Kristian, Awad A George   +6 more
doaj   +1 more source

Chlorpromazine versus placebo for schizophrenia

, 2007
Background: Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. Objectives: To evaluate the effects of chlorpromazine for schizophrenia in comparison with placebo.
Thornley, B., Adams, Clive, Awad, G., George Awad, Ben Thornley, Clive E Adams, Rathbone, J., John Rathbone   +7 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Beyond the Phenothiazine Core: Mechanistic Insights into the Three-Electron Oxidation of Chlorpromazine

Molecules
This study investigates the electrochemical oxidation mechanisms of chlorpromazine (CPZ), revealing a novel three-electron oxidation pathway that challenges the traditionally accepted two-electron paradigm, offering new insights into CPZ oxidation ...
Kiara T. Miller, Ashwin K. V. Mruthunjaya, Angel A. J. Torriero   +2 more
doaj   +1 more source