Results 51 to 60 of about 51,828 (245)

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Histological evaluation and E-cadherin and β-catenin expression in kidney of dogs submitted to renal ischemia and reperfusion after chlorpromazine administration

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Renal ischemia can be associated with some urological procedures, such as renovascular surgery or kidney transplantation, that are often followed by acute renal failure.
L.B. Menezes, M.C.S. Fioravanti, F.A. Oliveira, M.S.B. Silva, L.G. Franco, T.P. Sales, M.M. Andrascko, L.L.B. Guimarães, M.P. Miguel, E.G. Araújo   +9 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Effect of chlorpromazine on intact and irradiated aliquot ctdsDNA samples

مجلة كلية الطب, 2007
Bagkground:Chlorpromazine is widely used in human medicine in the therapy of schizophrenia, organic psychosis and the manic phase of manic depressive illness. It expressed a selective cytotoxicity and the results of genotoxicity were positive. Objectives:
Ali M. Abbed, Marwan S.M. Al-Nimer, Mohammad A. ALhamdany   +2 more
doaj  

Priapisme induit par la chlorpromazine: A propos de deux cas

African Journal of Urology, 2016
Le priapisme est une affection rare, l’implication de la chlorpromazine dans l’induction de cette affection est peu connue. Nous rapportons ici le cas de deux patients qui ont présenté un priapisme en concomitance avec une prescription de chlorpromazine.
I. Marrag, R. Ben Soussia, K. Hajji, L. Zarrouk, Y. Binous, M. Nasr   +5 more
doaj   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Beyond the Phenothiazine Core: Mechanistic Insights into the Three-Electron Oxidation of Chlorpromazine

Molecules
This study investigates the electrochemical oxidation mechanisms of chlorpromazine (CPZ), revealing a novel three-electron oxidation pathway that challenges the traditionally accepted two-electron paradigm, offering new insights into CPZ oxidation ...
Kiara T. Miller, Ashwin K. V. Mruthunjaya, Angel A. J. Torriero   +2 more
doaj   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

THE EFFECT OF LITHIUM ON ACUTE TOXICITY OF CHLORPROMAZINE IN MICE [PDF]

Acta Medica Iranica, 1996
The effects of chronic administration of lithium, on acute toxicity of chlorpromazine (CPZ) in male albino mice was studied and the LDSO values were determined from dose-probit curves.
Dehpour, A.R., Samini M. Rahimsalehi, V.
doaj  

Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials

BMC Medicine, 2005
Background Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated.
Borrill Jo, Clarke Mike, Thornley Ben, Rathbone John, Adams Clive, Wahlbeck Kristian, Awad A George   +6 more
doaj   +1 more source