Results 71 to 80 of about 36,001 (235)

Anti‐Erythrocyte Antibody Formation in Individuals With and Without Known Sensitisation Pathways Reflecting Indications for Extended Immunohaematology Screening

Journal of Clinical Laboratory Analysis, EarlyView.
– The yearly incidence of anti‐red blood cell antibodies stratified by participant groups and temporal evolution. – Overall significance p = 3.756 × 10−29. ABSTRACT Background Blood transfusion therapies are of vital importance for many patient groups.
Milanka Milosavić, Marko Lilić, Gordana Guzijan, Dušan Vučetić   +3 more
wiley   +1 more source

Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1

Advanced Science
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, a cell signaling‐focused CRISPR screen identified cytochrome c oxidase subunit 4 isoform 1 (COX4I1) as a
Leisi Zhang, Honghai Zhang, Ting‐Yu Wang, Mingli Li, Anthony K.N. Chan, Hyunjun Kang, Lai C. Foong, Qiao Liu, Sheela Pangeni Pokharel, Nicole M. Mattson, Priyanka Singh, Zeinab Elsayed, Benjamin Kuang, Xueer Wang, Steven T. Rosen, Jianjun Chen, Lu Yang, Tsui‐Fen Chou, Rui Su, Chun‐Wei David Chen   +19 more
doaj   +1 more source

Prolongation of certain effects of amphetamine by chlorpromazine

, 1969
This study examines the effect of chlorpromazine on the hypermotility and hyperthermia induced by amphetamine in rats and correlates the effects observed with brain levels of the stimulant.
A. Wojdan, L. Borella, F. Herr
core   +1 more source

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Indira Garcia‐Cordero, Mohsen Hadian, Juan Camilo Vargas‐Gonzalez, Marta Monteiro, David Gold, Abeer Khoja, Alonso Morales‐Rivero, Blas Couto, David Tang‐Wai, Susan Fox, Gabor G. Kovacs, Anthony E. Lang, Maria Carmela Tartaglia   +12 more
wiley   +1 more source

Pattern of Psychotropic Drug Prescription in the Elderly with Chronic Schizophrenia

Iranian Rehabilitation Journal, 2013
Objectives: Psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. The main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy ...
Mohamad Reza Khodaei Ardakani, Arash Mirabzadeh, Hashem Shemshadi, Zabihollah Ashtari, Maryam Ranjbar, Golnaz Feizzadeh, Mercedeh Samiei, Alireza Khodaei Ardakani   +7 more
doaj  

Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis

BMC Complementary and Alternative Medicine, 2017
Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting ...
Patrick Amoateng, Samuel Adjei, Dorcas Osei-safo, Kennedy K. E. Kukuia, Emelia Oppong Bekoe, Thomas K. Karikari, Samuel B. Kombian   +6 more
doaj   +1 more source

Tumor microenvironment responsive and nanozyme‐catalyzed photodynamic therapy via lysosome‐localized copper‐doped carbon dots

Responsive Materials, EarlyView.
The lysosome‐localized copper‐doped carbon dots (Cu‐MLCDs) leverage the high expression of glutathione (GSH)/H2O2 in the tumor microenvironment to achieve fluorescence reactivation enhancement. Through its multi‐nanozyme activities (glutathione peroxidase, peroxidase, and catalase), this nanoplatform relieves hypoxia, depletes GSH, and synergistically ...
Weixia Qin, Chengwei Hu, Haimei Zhu, Junjie Cui, Yaqing Cheng, Junfa Zhu, Qian Xu, Antonio Claudio Tedesco, Hong Bi   +8 more
wiley   +1 more source

Effects of Chlorpromazine on the Chromatophores of Frog Skin [PDF]

, 1972
Using the conventional in vitro frog skin bioassay technique, it has been shown that chlorpromazine can have a direct as well as an indirect effect on frog dermal chromatophores and that chlorpromazine darkened skin loses its ability to react either by ...
Irwin, William G.
core   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma

Frontiers in Immunology
BackgroundGlioblastoma (GBM), the most common and aggressive primary brain tumor in adults, poses a formidable therapeutic challenge, due to its intrinsic radio- and chemoresistance and its ability to create a hostile, immunosuppressive tumor ...
Giulia Fanelli, Luisa Gesualdi, Barbara Ascione, Francesca Paolini, Lucrezia Gambardella, Andrea Sacconi, Marco G. Paggi, Paola Matarrese, Claudia Abbruzzese   +8 more
doaj   +1 more source