Results 71 to 80 of about 51,331 (226)

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

Journal of Biological Chemistry, 1980
Ca2+-activated, phospholipid-dependent protein kinase recently found in mammalian tissues (Takai, Y., Kishimoto, A., Iwasa, Y., Kawahara, Y., Mori, T., and Nishizuka, Y. (1979) J. Biol. Chem.
T. Mori, Y. Takai, R. Minakuchi, B. Yu, Y. Nishizuka   +4 more
semanticscholar   +1 more source

A Zeolitic Pyrimidine Framework (ZPF) Nanoplatform Co‐Delivers a DNAzyme and a Protein Prodrug for Cascade‐Activated Tumour Therapy

Cell Proliferation, EarlyView.
A zeolitic framework co‐delivers a DNAzyme and a protein prodrug to tumour cells and executes a self‐amplifying therapeutic cascade: the DNAzyme elevates tumour oxidative stress to activate a caged RNase A prodrug. This spatiotemporally controlled synergy converts a genetic input into potent enzymatic cytotoxicity, suppressing tumour growth.
Yan Huang, Xingjie Hu, Jinli Sun, Min Yin, Nan Chen   +4 more
wiley   +1 more source

Pattern of Psychotropic Drug Prescription in the Elderly with Chronic Schizophrenia

Iranian Rehabilitation Journal, 2013
Objectives: Psychotropic drug use in the elderly with chronic schizophrenia is an important issue in the field of psychiatry. The main goal of this study was to clarify the pattern of such drug use in these patients, in order to consider such therapy ...
Mohamad Reza Khodaei Ardakani, Arash Mirabzadeh, Hashem Shemshadi, Zabihollah Ashtari, Maryam Ranjbar, Golnaz Feizzadeh, Mercedeh Samiei, Alireza Khodaei Ardakani   +7 more
doaj  

Biochemical Pathways Triggered by Antipsychotics in Human Oligodendrocytes: Potential of Discovering New Treatment Targets

Frontiers in Pharmacology, 2019
Schizophrenia is a psychiatric disorder that affects more than 21 million people worldwide. It is an incurable disorder and the primary means of managing symptoms is through administration of pharmacological treatments, which consist heavily of ...
Caroline Brandão-Teles, Valéria de Almeida, Juliana S. Cassoli, Juliana S. Cassoli, Daniel Martins-de-Souza, Daniel Martins-de-Souza, Daniel Martins-de-Souza   +6 more
doaj   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

Chlorpromazine as prophylaxis for bipolar disorder with treatment- and electroconvulsive therapy-refractory mania: Old horse, new trick

Indian Journal of Psychological Medicine, 2017
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3rd episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy.
Tamonud Modak, Saurabh Kumar, Arghya Pal, Rishab Gupta, Raman Deep Pattanayak, Sudhir Kumar Khandelwal   +5 more
doaj   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Exploring Current Emergency Medical Services Approaches to Manage Agitated Older Adult Patients: An Analysis of Statewide Protocols

Journal of the American Geriatrics Society, EarlyView.
Most state EMS protocols provide guidance on management of agitated patients, including use of physical restraints and chemical sedatives, yet older adult‐specific modifications or dosing guidance are uncommon. ABSTRACT Background Agitation in older adults presents unique challenges for emergency medical services (EMS) clinicians.
Joshua Lachs, Rana Barghout, William Haussner, David Hancock, Emily Benton, Maia Dorsett, Gregory Peters, Rebecca Cash, Joseph Holley, Tony Rosen   +9 more
wiley   +1 more source

Comparison of intramuscular haloperidol and other short-acting injectable antipsychotics for management of acute agitation in an adult inpatient psychiatry unit [PDF]

Mental Health Clinician
Introduction There is no consensus on the optimal antipsychotic for acute agitation. Whereas haloperidol is frequently used and has proven efficacy, second generation antipsychotics show similar efficacy and improved safety and tolerability.
Sarah Gamcsik, PharmD, Katie S. Adams, PharmD, BCPP, BCPS   +1 more
doaj   +1 more source

Links between trauma and psychotic symptoms: Integrating cognitive behavioural and neuropsychoanalytic models of psychosis

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Purpose Cognitive‐behavioural therapy for psychosis (CBTp) achieves small to modest effect sizes, which invites the question, ‘What clinical modifications might improve outcomes?’ This paper proposes an integration of CBTp with a neuropsychoanalytic approach that in clinical practice might extend the gains achieved by CBTp alone.
Michael Garrett
wiley   +1 more source