Results 81 to 90 of about 28,288 (192)

Impaired Neurosphere Formation as a Functional Readout of Aberrant EGFR Signaling Kinetics in Olfactory Neural Progenitors From Patients With Schizophrenia

open access: yesCell Biology International, Volume 50, Issue 7, July 2026.
ABSTRACT The Epidermal Growth Factor Receptor (EGFR) is a key regulator of neurodevelopment, controlling the proliferation, differentiation, and self‐renewal of neural stem and progenitor cells. Dysregulated EGFR signaling has been implicated in schizophrenia, a neurodevelopmental disorder associated with abnormal cortical maturation.
Tommaso Toffanin   +17 more
wiley   +1 more source

IN VITRO EFFECTS OF CHLORPROMAZINE AND HALOPERIDOL ON HUMAN ERYTHROCYTE GLUCOSE 6-PHOSPHATE DEHYDROGENASE ENZYME

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
Objective: Effects of chlorpromazine and haloperidol on erythrocyte glucose 6-phosphate dehydrogenase enzyme activity were investigated in invitro conditions. Methods: Glucose 6- phosphate dehydrogenase was purified from human erythrocyte.
Mehmet Emin Büyükokuroğlu   +4 more
doaj  

A Narrative Review of Artificial Intelligence for Drug Repurposing: Lessons From COVID‐19 and Oncology (2020–2025)

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Drug repurposing presents a cost‐effective and time‐efficient strategy to identify new therapeutic applications for existing drugs. Recent advances in artificial intelligence, including machine learning, deep learning, knowledge graphs, and natural language processing, have revolutionized this field by enabling automated discovery of drug ...
Alaba Bukola Ogungbite, Malusi Sibiya
wiley   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

open access: yesAging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang   +6 more
wiley   +1 more source

Chlorpromazine induced cataract in a young patient with schizophrenia

open access: yesIndian Journal of Psychological Medicine, 2010
There is resurgence of first generation antipsychotics use due to the metabolic side effects associated with the use of second generation antipsychotics. Lenticular and corneal abnormalities were reported earlier with Chlorpromazine.
Divakaran Anjith   +5 more
doaj  

Proteasome localization and activity in pig brain and in vivo small molecule screening for activators

open access: yesFrontiers in Cellular Neuroscience
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease.
Adriana Amrein Almira   +9 more
doaj   +1 more source

Chlorpromazine

open access: yesInternational Journal of Clinical Practice, 1956
openaire   +4 more sources

Prevalence of polypharmacy and factors impacting psychotropic prescribing patterns in women of childbearing potential at inpatient mental health services in Qatar

open access: yesNeuropsychopharmacology Reports
Aims Women may experience unique mental disorders due to hormone shifts. Rates of schizophrenia and bipolar disorder are similar between genders, but onset and symptoms may differ.
Nervana Elbakary   +11 more
doaj   +1 more source

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