Results 81 to 90 of about 51,331 (226)

Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma

Frontiers in Immunology
BackgroundGlioblastoma (GBM), the most common and aggressive primary brain tumor in adults, poses a formidable therapeutic challenge, due to its intrinsic radio- and chemoresistance and its ability to create a hostile, immunosuppressive tumor ...
Giulia Fanelli, Luisa Gesualdi, Barbara Ascione, Francesca Paolini, Lucrezia Gambardella, Andrea Sacconi, Marco G. Paggi, Paola Matarrese, Claudia Abbruzzese   +8 more
doaj   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats [PDF]

Eurasian Journal of Veterinary Sciences
Aim: This study was carried out to determine pathology of cadmium toxicity and protective effects of chlorpromazine in rats, simultaneously. Materials and Methods: Totally 64 Sprague-Dawley rats were divided into four equal groups.
Tuna Erdem, Fatih Hatipoğlu
doaj  

Electrochemical oxidation of Fe (II) using chlorpromazine drug at boron-doped diamond electrode: application to in vivo mechanism study interaction of chlorpromazine on hemoglobin iron and evaluation of some biomolecules

Materials Research Express
In this study, the electrochemical properties of aqueous chlorpromazine hydrochloride (CPZ) in the presence of Fe (II) were investigated by cyclic voltammetry at a boron-doped diamond (BDD) electrode.
Nader Amini, Kazhal Naderi, Abbas Ahmadi, Kambiz Hassanzadeh, Mohammad-Nazir Menbari, Mohammad Abdi, Ebrahim Ghaderi, Mohammad-Rezgar Zarehbin   +7 more
doaj   +1 more source

Network-driven prioritization and functional phenotyping nominate TTC23 as a biomarker-informed target in chlorpromazine repurposing for glioblastoma

Frontiers in Pharmacology
BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target triage to yield actionable and ...
Jianqiang Hao, Hongbin Liu, Yongqiang Ye, Jianwei Lv, Fang Xue, Yanli Cai   +5 more
doaj   +1 more source

Determination of Trace Levels of Nitrite in Beverages Samples Through Micellar Improved Catalytic Kinetic Spectrophotometry

Cumhuriyet Science Journal, 2017
In this study, a simple and sensitive catalytic kineticspectrophotometry method for determination of nitrite has been described. Themethod is based on the oxidation of chlorpromazine by nitrite in presence ofmixed surfactants in acidic medium, which ...
Adil Elik, Nail Altunay, Ramazan Gürkan
doaj   +1 more source

A multipurpose Voltammetric Sensor for the Determination of Chlorpromazine in Presence of Acetaminophen, Uric Acid, Dopamine and Ascorbic Acid

International Journal of Electrochemical Science, 2012
We report the fabrication and characterization of a voltammetric sensor for the determination of chlorpromazine (CPM) based on multiwalled carbon nanotube-polyethyleneimine (MWCNT-PEI) composite modified glassy carbon electrode (GCE).
Binesh Unnikrishnan, Pei-Chi Hsu, Shen-Ming Chen   +2 more
doaj   +1 more source

Mechanistic Insights Into the Photosensitizing Properties of the Topical Retinoid Tazarotene

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Light‐activated retinoids: Tazarotene and its active metabolite tazarotenic acid form long‐lived triplet excited states upon UVA irradiation, generating singlet oxygen and promoting photochemical reactions. These processes correlate with reduced fibroblast viability under light exposure, revealing potential phototoxicity and implications for combined ...
Juan A. Soler‐Orenes, Macarena Dillon, Gemma M. Rodríguez‐Muñiz, Matilde Ansino‐Ortiz, Inmaculada Andreu, Virginie Lhiaubet‐Vallet   +5 more
wiley   +1 more source

Chlorpromazine-Induced Severe Hyponatremia in 66 Years Old Patient

Acta Medica Indonesiana, 2023
Hyponatremia is a common clinical problem in older people. The aging process is usually accompanied by various maladaptations to stress in different organs and physiologic functions.
Sri Soenarti, Muchammad Kamal Hadi
doaj  

Allergy to chlorpromazine and valproic acid following carbamazepine hypersensitivity in a patient with an HLA-B*4601 allele

Neuropsychiatric Disease and Treatment, 2018
Kumi Sakurada,1,* Takeshi Kozaru,2,* Kazuo Yamada,1 Masashi Nibuya,1 Kiyoshi Nagata,3 Eiji Suzuki1 1Department of Psychiatry, 2Department of Dermatology, 3Department of Environmental and Health Science, Tohoku Medical and Pharmaceutical University ...
Sakurada K, Kozaru T, Yamada K, Nibuya M, Nagata K, Suzuki E   +5 more
doaj