Results 131 to 140 of about 4,518,745 (345)

How to think about designing smart antibodies in the age of genAI: integrating biology, technology, and experience

mAbs
Antibody discovery has been successful in designing and progressing molecules to the clinic and market based on largely empirical methods and human experience.
Andrew Buchanan, Eric Bennett, Rebecca Croasdale-Wood, Andreas Evers, Brian Fennell, Norbert Furtmann, Konrad Krawczyk, Sandeep Kumar, Christopher James Langmead, Melody Shahsavarian, Christine Elaine Tinberg   +10 more
doaj   +1 more source

Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders

Neurobiology of Disease, 1998
Unprecedented developments in cannabinoid research within the past decade include discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at
Paul Consroe
doaj   +1 more source

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]

, 2019
Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Newman, Amy H, Sedighim, Sharona   +4 more
core  

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

Journal of Translational Medicine, 2011
Background Accumulating evidence supports the role of the mineralocorticoid receptor (MR) in the pathogenesis of diabetic nephropathy. These findings have generated renewed interest in novel MR antagonists with improved selectivity against other nuclear ...
Eudy Rena J, Sahasrabudhe Vaishali, Sweeney Kevin, Tugnait Meera, King-Ahmad Amanda, Near Kristen, Loria Paula, Banker Mary, Piotrowski David W, Boustany-Kari Carine M   +9 more
doaj   +1 more source

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]

, 2015
Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
D'Oyley, JM, Dhankher, P, Gill-Thind, JK, Millar, NS, Sheppard, TD   +4 more
core  

Baseline characteristics and enrichment results from the SONAR trial [PDF]

, 2018
Aim: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in the urinary albumin‐to‐creatinine ratio [UACR]) and safety/
Andress, Dennis L., Bakris, George, Brennan, John J., Correa-Rotter, Ricardo, de Zeeuw, Dick, Heerspink, Hiddo J.L., Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John, Parving, Hans-Henrik, Perkovic, Vlado, Tobe, Sheldon, Wigderson, Melissa, Yi, Tingting   +15 more
core   +3 more sources

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, EarlyView.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

A validation of mobile sensing actigraphy devices for generating a biomechanical model of posture [PDF]

, 2017
Mobile sensing actigraphy was tested and validated as a modality for computing dynamic posturography. Twelve healthy volunteer subjects (6 male) were administered risperidone and assessed for postural stability using a NeuroCom® Balance Master system and
Detheridge, Craig Neal
core   +1 more source