Results 11 to 20 of about 4,518,745 (345)

Synergy, Additive Effects, and Antagonism of Drugs with Plant Bioactive Compounds

Drugs and Drug Candidates
Background/Objectives: The interaction of bioactive compounds derived from plants with drugs has become a significant area of investigation due to its potential to improve, reduce, or have no effect on therapeutic outcomes.
Noureddine Chaachouay
doaj   +2 more sources

Drug antagonism and single-agent dominance result from differences in death kinetics. [PDF]

Nat Chem Biol, 2020
Cancer treatment generally involves drugs used in combinations. Most previous work has focused on identifying and understanding synergistic drug–drug interactions; however, understanding antagonistic interactions remains an important and understudied ...
Richards R, Schwartz HR, Honeywell ME, Stewart MS, Cruz-Gordillo P, Joyce AJ, Landry BD, Lee MJ.   +7 more
europepmc   +2 more sources

An ATP-Binding Cassette Pleiotropic Drug Transporter Protein Is Required for Xenobiotic Tolerance and Antagonism in the Fungal Biocontrol Agent Clonostachys rosea

Molecular Plant-Microbe Interactions, 2014
ATP-binding cassette (ABC) transporters mediate active efflux of natural and synthetic toxicants and are considered to be important for drug tolerance in microorganisms.
Mukesh K. Dubey, Dan Funck Jensen, Magnus Karlsson   +2 more
doaj   +2 more sources

Parameters of drug antagonism: re-examination of two modes of functional competitive drug antagonism on intraocular muscles

Journal of Pharmacy and Pharmacology, 2004
Abstract There are two distinct kinetic functional pharmacological procedures by which the equilibrium affinity constant, KB, of a competitive reversible blocker is obtained. The classical method on an organ system requires the study of the parallel displacement of the agonist concentration-response curve in the presence of the blocker ...
P. Patil
openaire   +3 more sources

pA_x AND COMPETITIVE DRUG ANTAGONISM [PDF]

British Journal of Pharmacology and Chemotherapy, 1949
H. Schild
openaire   +3 more sources

Drug antagonism. [PDF]

BMJ, 1971
L. Mackie
openaire   +3 more sources

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

Cell Research, 2022
The SARS-CoV-2 Omicron variant is currently causing a large number of infections in many countries. A number of antiviral agents are approved or in clinical testing for the treatment of COVID-19.
D. Bojkova, M. Widera, S. Ciesek, Mark N. Wass, M. Michaelis, J. Cinatl   +5 more
semanticscholar   +1 more source

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2018
para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB is limited by its lower potency against Mycobacterium tuberculosis relative to ...
Michael D. Howe, Shannon L. Kordus, Malcolm S. Cole, Allison A. Bauman, Courtney C. Aldrich, Anthony D. Baughn, Yusuke Minato   +6 more
doaj   +1 more source

From a Pathophysiological Concept to a New Drug

European Psychiatry, 2022
Although antipsychotics were discovered over fifty years ago, it took another decade until dopamine antagonism was demonstrated as central to their clinical effectiveness.
G. Németh
doaj   +1 more source

CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]

, 2015
Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A., Doncheck, Elizabeth M., Ganzman, Geoffrey S., Hillard, Cecilia J., Mantsch, John R., McReynolds, Jayme R., Vranjkovic, Oliver   +6 more
core   +2 more sources