Results 11 to 20 of about 176,232 (313)

An R Package for Assessing Drug Synergism/Antagonism [PDF]

Journal of Statistical Software, 2010
Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
John C. Boik, Balasubramanian Narasimhan
doaj   +1 more source

Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma

Acta Pharmaceutica Sinica B, 2022
Pancreatic cancer remains one of the most lethal malignancies worldwide. The combination of the first-line standard agent gemcitabine (GEM) with the molecular-targeted drug erlotinib (Er) has emerged as a promising strategy for pancreatic cancer ...
Honglin Tang, Yanan Xue, Bowen Li, Xiaojie Xu, Fu Zhang, Jiajing Guo, Qijun Li, Tingting Yuan, Yuan Chen, Yubin Pan, Yuan Ping, Da Li   +11 more
doaj   +1 more source

Assessing synergy or antagonism for drug combinations [PDF]

Nature Reviews Drug Discovery, 2004
Angus Bell, Stella G. Machado
openaire   +3 more sources

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Frontiers in Psychiatry, 2022
IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence.
Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, Dana G. Smith, John Suckling, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson   +20 more
doaj   +1 more source

Decoding the Postulated Entourage Effect of Medicinal Cannabis: What It Is and What It Isn’t

Biomedicines, 2023
The ‘entourage effect’ term was originally coined in a pre-clinical study observing endogenous bio-inactive metabolites potentiating the activity of a bioactive endocannabinoid.
Catalina Christensen, Martin Rose, Claus Cornett, Morten Allesø   +3 more
doaj   +1 more source

Renal fibrosis due to multiple cisplatin treatment is exacerbated by kinin B1 receptor antagonism

Brazilian Journal of Medical and Biological Research, 2021
Cisplatin is a widely used chemotherapeutic drug, but its side effects are a major limiting factor. Nephrotoxicity occurs in one third of patients undergoing cisplatin treatment.
A. Budu, L.C. Freitas-Lima, A.C. de Arruda, M.S. Perilhão, J. Barrera-Chimal, R.C. Araújo, G.R. Estrela   +6 more
doaj   +1 more source

Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus. [PDF]

, 2015
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) are prevalent and the ...
A Anantharaman, A Elemam, A Giacometti, AF Zuluaga, AL Barry, Alexander Liu, Angela Kearns, Anthony Coates, AR Coates, B Mazurek, B Zechini, Brigita Vaiciunaite, C Ostergaard, CA Arias, Christiana Moigboi, CT Mascio, D Andes, D Harmsen, DE Fry, EJ Toone, EL Chan, FC Odds, H Lam, HW Boucher, J Yoon, James Vaudrey, JM Pages, JR Aeschlimann, K Hiramatsu, KS Brinch, L Cui, L Kalan, M Aligholi, M Magret, M Shahid, M Wu, NC Gordon, Oliver Schildgen, P Cottagnoud, PE Reynolds, PH Mygind, RC Moellering Jr, RE Hancock, RL Hill, Sharla M. McTavish, T Schneider, W Yuan, WE Alborn Jr, Y Hu, Y Hu, Y Quiros, Y Zhang, Yanmin Hu, YQ Xiong   +53 more
core   +10 more sources

Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC

Drug Delivery, 2022
Due to the lack of safe, effective, and gene-targeted delivery technology. In this study, we have prepared nanobubbles loaded PDLIM5 siRNA (PDLIM5siRNA-NBs) to investigate the transfection efficiency and their antagonism in drug resistance in combination
Chunhong Su, XiaoJun Ren, Fang Yang, Bin Li, Hao Wu, Hui Li, Fang Nie   +6 more
doaj   +1 more source

Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]

, 2018
Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S, Minzenberg, Michael J, Soosman, Steffan K, Yoon, Jong H   +3 more
core   +3 more sources

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources