Results 51 to 60 of about 4,518,745 (345)

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

The Lancet Microbe, 2021
Background The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03.
S. Schroeder, F. Pott, Daniela Niemeyer, Talitha Veith, A. Richter, D. Muth, C. Goffinet, M. Müller, C. Drosten   +8 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science
Targeted drug design and development, as a core area of modern pharmaceutical research, critically depends on the assessment of protein site druggability as a fundamental component.
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
doaj   +1 more source

Molecular tuning of farnesoid X receptor partial agonism

Nature Communications, 2019
The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR ...
Daniel Merk, Sridhar Sreeramulu, Denis Kudlinzki, Krishna Saxena, Verena Linhard, Santosh L. Gande, Fabian Hiller, Christina Lamers, Ewa Nilsson, Anna Aagaard, Lisa Wissler, Niek Dekker, Krister Bamberg, Manfred Schubert-Zsilavecz, Harald Schwalbe   +14 more
doaj   +1 more source

When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition.

PLoS Biology, 2013
Conventional wisdom holds that the best way to treat infection with antibiotics is to 'hit early and hit hard'. A favoured strategy is to deploy two antibiotics that produce a stronger effect in combination than if either drug were used alone.
Rafael Pena-Miller, David Laehnemann, Gunther Jansen, Ayari Fuentes-Hernandez, Philip Rosenstiel, Hinrich Schulenburg, Robert Beardmore   +6 more
doaj   +1 more source

Potency of vancomycin against Mycobacterium tuberculosis in the hollow fiber system model

Journal of Global Antimicrobial Resistance, 2021
Objectives: To determine whether an inhaled vancomycin formulation resulting in high intrapulmonary 24-h area under the concentration–time curve (AUC0–24) could be optimised for tuberculosis treatment.
Shashikant Srivastava, Moti Chapagain, Johanna van Zyl, Devyani Deshpande, Tawanda Gumbo   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish

Frontiers in Pharmacology
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions.
Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea Mcquate, Andrea Mcquate, Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, Henry C. Ou, David W. Raible, David W. Raible, David W. Raible, Rafael E. Hernandez, Rafael E. Hernandez, Shuyi Ma, Shuyi Ma, Shuyi Ma, Shuyi Ma   +20 more
doaj   +1 more source

Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism

BMC Cancer, 2021
Background Evidence bearing on the role of statins in the prevention and treatment of cancer is confounded by the diversity of statins, chemotherapeutic agents and cancer types included in the numerous published studies; consequently, the adjunctive ...
Kaitlyn A. Khandelwal Gilman, Seungmin Han, Young-Wook Won, Charles W. Putnam   +3 more
doaj   +1 more source

Potential biomarker of brain response to opioid antagonism in adolescents with eating disorders: a pilot study

Frontiers in Psychiatry, 2023
BackgroundEating Disorders (ED) affect up to 5% of youth and are associated with reward system alterations and compulsive behaviors. Naltrexone, an opioid antagonist, is used to treat ED behaviors such as binge eating and/or purging.
Stephani L. Stancil, Stephani L. Stancil, Stephani L. Stancil, Hung-Wen Yeh, Hung-Wen Yeh, Morgan G. Brucks, Amanda S. Bruce, Amanda S. Bruce, Michaela Voss, Susan Abdel-Rahman, William M. Brooks, William M. Brooks, Laura E. Martin, Laura E. Martin   +13 more
doaj   +1 more source