Results 71 to 80 of about 4,518,745 (345)
Antagonism between Two Mechanisms of Antifungal Drug Resistance [PDF]
Eukaryotic Cell, 2006 ABSTRACT This study tested for interaction between two independently evolved mechanisms of fluconazole resistance in Saccharomyces cerevisiae . One set of strains was from a 400-generation evolution experiment, during which the concentration of fluconazole was increased from 16 to 256 μg/ml in four ...
James B, Anderson +2 more
openaire +2 more sources
Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men [PDF]
, 2015 We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men.
Areberg, J +4 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Systems BiologyAntibiotic combinations aim to maximise drug treatment efficiency and minimise resistance evolution, but a full understanding of their effect on bacterial cells is lacking.
James Broughton +2 more
doaj +1 more source
Antagonism of a PCP Drug Discrimination by Hallucinogens and Related Drugs [PDF]
Neuropsychopharmacology, 2000 Drugs such as PCP and MK-801 can cause psychotic reactions in humans by antagonizing NMDA receptors. This action is ultimately toxic to certain cortical neurons and may be one mechanism underlying neurodegenerative diseases, including schizophrenia. It has been reported that hallucinogens such as LSD, DOM, and DOI can block the neurotoxic effects of ...
W B, West +4 more
openaire +2 more sources
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]
, 2019 Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Эпилепсия и пароксизмальные состояния, 2019 The aim is to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.Materials and methods.
G. G. Avakyan +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs. [PDF]
Blood, 2005 Abstract Vitamin C is an antioxidant vitamin that has been hypothesized to antagonize the effects of antineoplastic drugs that generate reactive oxygen species. Leukemia (K562) and lymphoma (RL) cells pre-treated with dehydroascorbic acid, the commonly transported form of vitamin C, demonstrated a dose-dependent attenuation of ...
Mark L, Heaney +6 more
openaire +3 more sources