Results 131 to 140 of about 999,693 (251)

Drug approvals [PDF]

Nature, 1992
openaire   +1 more source

Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper. [PDF]

J Pediatr Gastroenterol Nutr
Turner D, Assa A, Malham M, Bar-Asher SY, Rayan C, Hyams JS, Uhlig HH, Pasternak B, Wilson DC, Michel HK, de Ridder L, Zuckerman E, Aloi M, Szitanyi P, Dubinsky MC, Griffiths AM, Saldana R, Martín-de-Carpi J, Wine E, Russell RK, Adler J, Picoraro J.   +21 more
europepmc   +1 more source

Twelve years of European cancer drug approval-a systematic investigation of the 'magnitude of clinical benefit'. [PDF]

ESMO Open, 2021
Grössmann N, Wolf S, Rothschedl E, Wild C.   +3 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Importance of Cost-Effectiveness in New Drug Approval: Stroke Burden and Tenecteplase Efficacy. [PDF]

J Clin Neurol
Kwon HS, Kim BJ.
europepmc   +1 more source

Conditional Drug Approval as a Path to Market for Oncology Drugs in Canada: Challenges and Recommendations for Assessing Eligibility and Regulatory Responsiveness. [PDF]

Front Med (Lausanne), 2021
McPhail M, Weiss E, Bubela T.
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Drug development for leukemia: comprehensive analysis of clinical trials from first report to drug approval. [PDF]

Blood Adv
Tjioe KC, Miranda-Galvis M, Mamouni K, Freitas T, Sharara M, Santellano B, Guillén-Lopez C, Cortes JE.   +7 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Novel drug approval by the FDA: Ekterly (Sebetralstat), oral plasma kallikrein inhibitor for treating acute attacks of hereditary angioedema. [PDF]

Ann Med Surg (Lond)
Gulalai, Miraj SA, Mahato RK.
europepmc   +1 more source