Results 111 to 120 of about 578,551 (263)

Neuromuscular Blocking Drugs [PDF]

Journal of the Royal Society of Medicine, 2002
openaire   +3 more sources

Think Beyond The Core: Computationally Decoding the Hydrophilic Corona of Drug-Loaded Polymer Micelles. [PDF]

Small
Karachevtsev M, Kehrein J, Hukka T, Bunker A, Karttunen M, Luxenhofer R.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Fentanyl purity and overdose decline: A reexamination of geographic trends. [PDF]

Sci Adv
Dasgupta N, Sibley A, Gildner P, Gora Combs K, Post LA, Tobias S, Kral AH, Liccardo Pacula R.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Anatomical evaluation of injectate spread in thoraco-lumbar interfascial plane block and lumbar erector spinae plane block: A cadaveric study. [PDF]

Indian J Anaesth
Hussain SY, Majage S, Jain D, Kumar S, Nagarajappa A, Lalwani S.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Quantum-mechanical insights into sodium alginate gelation and AI-driven discovery of synthetic biomimetic analogs. [PDF]

J Comput Aided Mol Des
Hussan KPS, Sooraj Kumar S, Varghese JK, Kita R, Shinyashiki N.   +4 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Prognosis of drug-induced atrioventricular block

Indian Heart Journal, 2014
A.K. Boro, P.K. Gupta, H. Rahman, K.C. Narzary, S.K.S. Boro   +4 more
doaj   +1 more source