Results 91 to 100 of about 5,260,545 (402)

Controlled Nanoparticle Formation by Diffusion Limited Coalescence [PDF]

, 2012
Polymeric nanoparticles (NPs) have a great application potential in science and technology. Their functionality strongly depends on their size. We present a theory for the size of NPs formed by precipitation of polymers into a bad solvent in the presence
Lebouille, J. G. J. L., Slot, J. J. M., Stepanyan, R., Stuart, M. A. Cohen, Tuinier, R.   +4 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy

Advanced Science, 2023
Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific locations in a controlled manner. Here, the study presents a novel nanoplatform constructed using zeolitic imidazolate framework‐8 (ZIF‐8), a nanoscale metal ...
Yuping Chen, Ruyin Lyu, Jie Wang, Qichao Cheng, Yanfang Yu, Shuxu Yang, Chuanbin Mao, Mingying Yang   +7 more
doaj   +1 more source

Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin [PDF]

, 1985
In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cytotoxic ...
Feijen, J., Greve, J., Grooth, B.G. de, Heeswijk, W.A.R., Hoes, C.J.T., Mud, J., Potman, W.   +6 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Lactose Engineering for Better Performance in Dry Powder Inhalers [PDF]

Advanced Pharmaceutical Bulletin, 2012
Dry powder inhaler (DPI) is generally formulated as a powder mixture of coarse carrier particles and micronized drug with aerodynamic diameters of 1-5 μm.
Yahya Rahimpour, Hamed Hamishehkar
doaj  

Alginate electrodeposition onto three-dimensional porous Co-Ni films as drug delivery platforms [PDF]

, 2015
Three-dimensional porous Co–Ni films/alginate hybrid materials have been successfully prepared by electrodeposition to be used as a steerable magnetic device for drug delivery. Firstly, 3D porous Co–Ni films were prepared as substrates for the subsequent
García Torres, José Manuel, Gispert, Claudia, Gómez, Elvira, Vallés, Elisa   +3 more
core   +2 more sources

Carrier-Mediated intestinal Transport of Drugs

Japanese Journal of Pharmacology, 1996
Recent advances in the field of carrier-mediated intestinal absorption of of amino acids, oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water-soluble vitamins across brush-border and basolateral membranes are summarized. An understanding of the molecular and functional characteristics of the intestinal membrane
A, Tsuji, I, Tamai
openaire   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]

, 2019
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B., Dave, Vivek S, Patil, Arun T., Pethe, Anil M., Raut, Nishikant, Telange, Darshan R., Umekar, Milind J.   +6 more
core   +1 more source