Results 161 to 170 of about 5,260,545 (402)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Synthesis of High-Precision Sub-Micron CaCO₃ Anticancer Drug Carriers from Coral Remains

Applied Sciences
Calcium carbonate (CaCO3) particles have attracted increasing attention as a promising material for drug delivery systems. In this study, coral remains were utilized as a raw material for a novel drug carrier.
Pin-Han Chen, Wei-Sheng Chen, Szu-An Chen, Wei-Chung Chen   +3 more
doaj   +1 more source

Engineering the drug carrier biointerface to overcome biological barriers to drug delivery.

Advanced Drug Delivery Reviews, 2020
J. Finbloom, F. Sousa, M. Stevens, T. Desai   +3 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications

Frontiers in Pharmacology
Bletilla striata is a traditional Chinese medicine (TCM) used for hemostasis, detumescence, and tissue regeneration. Its major bioactive component, Bletilla striata polysaccharide (BSP), is a water-soluble heteropolysaccharide composed primarily of ...
Bo Wang, Chaomeng Wu, Yingjuan Ma, Xiaofen Liu, Lijun Tao, Xuebing Zhou, Limin Jia, Limin Jia   +7 more
doaj   +1 more source

Montmorillonite as Anti-Tuberculosis Rifampicin Drug Carrier – DFT and Experimental Study [PDF]

, 2020
Eva Scholtzová, Ľuboš Jankovič, Daniel Tunega   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Brief Insight on Nanovesicular Liposomes as Drug-delivery Carriers for Medical Applications [PDF]

, 2023
Madhavi Pravinkumar Chudasma, Sakshi Alpeshkumar Shah, Mohammad Hamran Nasiruddin Qureshi, Nirav N. Shah, Devarshi Shah, Riddhi Trivedi, Viral Shah   +6 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Novel Molecules for Intra-Oral Delivery of Antimicrobials to Prevent and Treat Oral Infectious Diseases [PDF]

, 2008
New molecules were designed for efficient intra-oral delivery of antimicrobials to prevent and treat oral infection. The salivary statherin fragment, which has high affinity for the tooth enamel, was used as a carrier peptide. This was linked through the
Dentino, Andrew R., Raj, Periathamby A., Rajkumar, Latha   +2 more
core   +1 more source