Results 41 to 50 of about 207,835 (296)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Functionalized Halloysite Nanotubes as Potential Drug Carriers

Journal of Functional Biomaterials, 2023
The aim of the work was to examine the possibility of using modified halloysite nanotubes as a gentamicin carrier and to determine the usefulness of the modification in terms of the effect on the amount of the drug attached, its release time, but also on
Ewa Stodolak-Zych, Alicja Rapacz-Kmita, Marcin Gajek, Agnieszka Różycka, Magdalena Dudek, Stanisława Kluska   +5 more
doaj   +1 more source

Drug Carrier for Photodynamic Cancer Therapy [PDF]

International Journal of Molecular Sciences, 2015
Photodynamic therapy (PDT) is a non-invasive combinatorial therapeutic modality using light, photosensitizer (PS), and oxygen used for the treatment of cancer and other diseases. When PSs in cells are exposed to specific wavelengths of light, they are transformed from the singlet ground state (S0) to an excited singlet state (S1–Sn), followed by ...
Tilahun Debele, Sydney Peng, Hsieh-Chih Tsai   +2 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Feasibility of a High-Dose Inhaled Indomethacin Dry Powder with Dual Deposition for Pulmonary and Oral Delivery

Pharmaceutics
In this study we have developed a high-dose dry powder inhaler formulation of indomethacin using a novel approach to carrier-based formulations. Specifically, larger drug particles serve as the carrier for the smaller micronized drug particles, such that
Jamie E. Spahn, Amr Hefnawy, Feng Zhang, Hugh D. C. Smyth   +3 more
doaj   +1 more source

Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy

Advanced Science, 2023
Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific locations in a controlled manner. Here, the study presents a novel nanoplatform constructed using zeolitic imidazolate framework‐8 (ZIF‐8), a nanoscale metal ...
Yuping Chen, Ruyin Lyu, Jie Wang, Qichao Cheng, Yanfang Yu, Shuxu Yang, Chuanbin Mao, Mingying Yang   +7 more
doaj   +1 more source

pH-Dependent Behavior of Novel 5-FU Delivery System in Environmental Conditions Comparable to the Gastro-Intestinal Tract

Pharmaceutics, 2023
A biogenic carrier for 5-fluorouracil (5-FU) loading and subsequent tableting as a new drug formulation for slow release has been proposed using the biomineral from blue crab carapace.
Geza Lazar, Fran Nekvapil, Branko Glamuzina, Tudor Tamaș, Lucian Barbu-Tudoran, Maria Suciu, Simona Cinta Pinzaru   +6 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation

Journal of Nanobiotechnology
Spinal cord injury (SCI) often accompanies impairment of motor function, yet there is currently no highly effective treatment method specifically for this condition.
Tianjun Chen, Li Wan, Yongchun Xiao, Ke Wang, Ping Wu, Can Li, Caiqiang Huang, Xiangge Liu, Wei Xue, Guodong Sun, Xin Ji, Hongsheng Lin, Zhisheng Ji   +12 more
doaj   +1 more source

In Vitro Studies of Pegylated Magnetite Nanoparticles in a Cellular Model of Viral Oncogenesis: Initial Studies to Evaluate Their Potential as a Future Theranostic Tool

Pharmaceutics, 2023
Magnetic nanosystems represent promising alternatives to the traditional diagnostic and treatment procedures available for different pathologies. In this work, a series of biological tests are proposed, aiming to validate a magnetic nanoplatform for ...
Gabriel Principe, Virginia Lezcano, Silvina Tiburzi, Alicia B. Miravalles, Paula S. Rivero, María G. Montiel Schneider, Verónica Lassalle, Verónica González-Pardo   +7 more
doaj   +1 more source