Results 81 to 90 of about 5,260,545 (402)

The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]

, 2014
The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi, Barzegar-Jalali M, Clegg DO, Ford JL, Hiba Al-Hamidi, Horton D, Kofi Asare-Addo, Mike Kitson, Sandip Desai   +8 more
core   +1 more source

Restoration of Mir-185 in Combination with BCR-ABL Downregulation By Therapeutic Delivery of siRNA with Lipid Nanoparticle Carriers Targets Drug Resistant Leukemic Stem/Progenitor Cells [PDF]

, 2023
Athena Phoa, Min Chen, Xiaoyan Jiang
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Research progress of calcium carbonate nanomaterials in cancer therapy: challenge and opportunity

Frontiers in Bioengineering and Biotechnology, 2023
Cancer has keeping the main threat to the health of human being. Its overall survival rate has shown rare substantial progress in spite of the improving diagnostic and treatment techniques for cancer in recent years.
Tiantian Liang, Tiantian Liang, Zongqi Feng, Zongqi Feng, Zongqi Feng, Xiao Zhang, Xiao Zhang, Xiao Zhang, Tianfang Li, Tianfang Li, Tianfang Li, Tingyu Yang, Tingyu Yang, Tingyu Yang, Lan Yu, Lan Yu, Lan Yu   +16 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment

Bioactive Materials
Periodontitis is a chronic inflammatory disease caused by bacterial infection that leads to the destruction of periodontal tissues. Traditional treatment involves scaling and root planing combined with antibiotics, but systemic antibiotic therapy often ...
Xiang Yu, Huiling Liu, Lingdi Chen, Xiaohui Cheng, Gang Wu, Tim Forouzanfar, Longbao Feng, Rui Guo, Miao Zhou, Ting Sun   +9 more
doaj   +1 more source

Enhancement of Dissolution Rate of Olmesartan Medoxomil Using Urea as Carrier by Different Solid Dispersion Techniques [PDF]

, 2018
The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. As per Biopharmaceutical Classification System (BCS), Olmesartan belongs to the class-II category having ...
Gomathi, M. (M), Sangameswaran, B. (B)
core  

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source

Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles

Scientific Reports, 2017
Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects.
Haneul Kim, A. Jo, Seulgi Baek, Daeun Lim, S. Park, Soo Kyung Cho, J. Chung, Jinhwan Yoon   +7 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source