Results 111 to 120 of about 1,477,269 (300)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Treatment of fevers prior to introducing rapid diagnostic tests for malaria in registered drug shops in Uganda. [PDF]

, 2013
BACKGROUND: Since drug shops play an important role in treatment of fever, introducing rapid diagnostic tests (RDTs) for malaria at drug shops may have the potential of targeting anti-malarial drugs to those with malaria parasites and improve rational ...
Cundill, Bonnie, Clarke, Siân, Magnussen, Pascal, Mbonye, Anthony K, Hansen, Kristian Schultz, Mbonye, Anthony K., Lal, Sham   +6 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Patterns of anti-malarial drug treatment among pregnant women in Uganda. [PDF]

, 2011
BACKGROUND: Prompt use of an effective anti-malarial drug is essential for controlling malaria and its adverse effects in pregnancy. The World Health Organization recommends an artemisinin-based combination therapy as the first-line treatment of ...
Staedke Sarah G, Sarah G Staedke, Brentlinger Paula E, Andy Stergachis, Paula E Brentlinger, Stergachis, Andy, Laura R Sangaré, Richardson, Barbra A, Staedke, Sarah G, Weiss Noel S, Barbra A Richardson, Weiss, Noel S, Stergachis Andy, Mpungu S Kiwuwa, Kiwuwa, Mpungu S, Sangaré Laura R, Brentlinger, Paula E, Kiwuwa Mpungu S, Richardson Barbra A, Noel S Weiss, Sangaré, Laura R   +20 more
core   +1 more source

Pharmacokinetic parameters and optimal dosage of a florfenicol and tylosin mixture in beagle dogs

Veterinární Medicína, 2018
The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle ...
A.F. Mechesso, S.J. Lee, N.H. Park, S.C. Park   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems [PDF]

, 2012
Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years.
Raja, Shaista, Ali Nokhodchi, Shaista Raja, Pryia Patel, Asare-Addo, Kofi, Patel, Pryia, Kofi Asare-Addo, Shaista Raja (16203524), Nokhodchi, Ali, Priya Patel (679595), Ali Nokhodchi (4465915), Kofi Asare-Addo (4172488)   +11 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Adverse drug events resulting from use of drugs with sulphonamide-containing anti-malarials and artemisinin-based ingredients: findings on incidence and household costs from three districts with routine demographic surveillance systems in rural Tanzania. [PDF]

, 2013
BACKGROUND: Anti-malarial regimens containing sulphonamide or artemisinin ingredients are widely used in malaria-endemic countries. However, evidence of the incidence of adverse drug reactions (ADR) to these drugs is limited, especially in Africa, and ...
Abdulnoor M Kabanywanyi, Catherine A Goodman, Bloland, Peter B, Abdulla, Salim M, Kapella, Bryan K, Kahigwa, Elizeus, Elizeus Kahigwa, S Kachur, Kabanywanyi, Abdulnoor M, Peter B Bloland, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, John E Gimnig, Gimnig, John E, Macarthur, John R, Bryan K Kapella, Joseph D Njau, John R MacArthur, Salim M Abdulla   +19 more
core   +1 more source