Results 201 to 210 of about 1,477,269 (300)

Multi agent large language models for biomedical hypothesis generation in drug combination discovery. [PDF]

iScience
Xu Q, Soto C, Shahnawaz M, Liu X, Jiang X, Kim Y.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Three-drug combination therapy to prevent glucocorticoid-associated osteonecrosis in patients with systemic lupus erythematosus: a proof-of-concept study. [PDF]

Ther Adv Musculoskelet Dis
Motomura G, Arinobu Y, Niiro H, Hiramoto K, Kaneko Y, Kato M, Takeyama S, Furuta S, Nakajima H, Nakashima R, Yoshifuji H, Kuroda T, Amano K, Matsushita M, Yamaji K, Sonomoto K, Tanaka Y, Himuro N, Miyake K, Maruyama A, Tada Y, Nomura A, Okada M, Kishimoto J, Nakashima Y, Yamamoto T.   +25 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Drug Combination Recommendation Model for Systemic Lupus Erythematosus and Antiphospholipid Syndrome. [PDF]

Pharmaceuticals (Basel)
Wang L, Zhang Z, Zhang Z, Zhou TH, Ryu KH.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Monitoring of dual-drug combination therapy in pediatric epilepsy patients: a machine learning model for simultaneous VPA-LEV concentration-dose prediction. [PDF]

J Transl Med
Chen YW, Chen S, Xie YW, Zou H, Rao X, Xu JW, Wu W, Liu ZJ.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A highly annotated drug combination resource for catalyzing precision combinatorial therapy. [PDF]

Sci Data
You T, Wang L, Wang J, Xu D, Xu X, Li N, Li MJ, Wang H, Dong X.   +8 more
europepmc   +1 more source