Results 241 to 250 of about 1,477,269 (300)

Accurate prediction of synergistic drug combination using a multi-source information fusion framework. [PDF]

BMC Biol
Jin S, Long H, Huang A, Wang J, Yu X, Xu Z, Xu J.   +6 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Toward a Bactericidal Oral Drug Combination for the Treatment of Mycobacterium abscessus Lung Disease. [PDF]

ACS Infect Dis
Sarathy JP, Xie M, Wong CF, Negatu DA, Rodriguez S, Zimmerman MD, Jimenez DC, Alshiraihi IM, Gonzalez-Juarrero M, Dartois V, Dick T.   +10 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

RBC Membrane-Camouflaged Nanosystem-Mediated Synergistic Drug Combination for Enhanced Anti-Tumor Therapy. [PDF]

Adv Healthc Mater
Cheng Q, Zhong X, Deng L, He X, Luo M, Wang R, Zhang J.   +6 more
europepmc   +1 more source

MD-Syn: synergistic drug combination prediction based on a multidimensional feature fusion method and attention mechanisms. [PDF]

Front Pharmacol
Ge X, Lee YT, Yeh SJ.
europepmc   +1 more source

Exploration of metformin-based drug combination for mitigating diabetes-associated atherosclerotic diseases. [PDF]

World J Diabetes
Qu B, Li Z, Hu W.
europepmc   +1 more source