Results 241 to 250 of about 5,698,960 (306)

Synergistic Antimalarial Activity of Alpha-Mangostin Chitosan Alginate Nanoparticles with Chloroquine in Mice Infected with <i>Plasmodium berghei</i>: The Potential of a New Antimalarial Drug Combination. [PDF]

Iran J Med Sci
Tjahjani S, Hermanto F, Muchtaridi M, Aulifa DL, Haq FA.   +4 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Experimental Trypanosoma cruzi infection cured with a mechanistically distinct drug combination

Francisco AF, Olmo F, Escudié F, Chatelain E, Kelly JM.   +4 more
europepmc   +1 more source

Scaling up drug combination surface prediction. [PDF]

Brief Bioinform
Huusari R, Wang T, Szedmak S, Dias D, Aittokallio T, Rousu J.   +5 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Monitoring of dual-drug combination therapy in pediatric epilepsy patients: a machine learning model for simultaneous VPA-LEV concentration-dose prediction. [PDF]

J Transl Med
Chen YW, Chen S, Xie YW, Zou H, Rao X, Xu JW, Wu W, Liu ZJ.   +7 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Drug combination discovery assisted by AI and untargeted metabolomics: pamiparib and anlotinib synergistic potentiation for ovarian cancer treatment. [PDF]

Front Pharmacol
Wang D, Chu B, Wen T, Wang X, Li Y, Chen H, Zhang Z, Sun H.   +7 more
europepmc   +1 more source

Benchmarking Large Language Models for Drug Combination Alerts: Achieving Expert-Level Reliability via Knowledge Grounding and Contextual Reasoning. [PDF]

J Med Chem
Hu H, Wang L, Chen LQ, Lin H, Huang LT, Wang ZW, Hou XM.   +6 more
europepmc   +1 more source