Results 111 to 120 of about 737,831 (320)

Prediction of drug combinations by integrating molecular and pharmacological data.

PLoS Computational Biology, 2011
Combinatorial therapy is a promising strategy for combating complex disorders due to improved efficacy and reduced side effects. However, screening new drug combinations exhaustively is impractical considering all possible combinations between drugs ...
Xing-Ming Zhao, Murat Iskar, Murat Iskar, Georg Zeller, Michael Kuhn, Vera van Noort, Peer Bork   +6 more
doaj   +1 more source

USE OF ACETANILID IN VARIOUS COMBINATIONS AS A SUBSTITUTE FOR MANY PROPRIETARY DRUGS AND MIXTURES. [PDF]

, 1899
LOUIS FAUGÈRES BISHOP
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines

Molecules, 2017
β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER) and valencene (VAL) are constituents of the essential oil of Myrica rubra (MEO), which has significant antiproliferative effect in various cancer cell lines.
Martin Ambrož, Petra Matoušková, Adam Skarka, Martina Zajdlová, Kateřina Žáková, Lenka Skálová   +5 more
doaj   +1 more source

Differential Spectrometric Determination of Caffeine in Soluble Coffee and in Drug Combinations [PDF]

, 1968
William P. Ferren, Norman Shane
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

ACTION OF THREE DRUG COMBINATIONS ON GONOCOCCI [PDF]

, 1968
L. P. Garrod, P. M. Waterworth
openalex   +1 more source

Antihypertensive drug combinations [PDF]

Journal of the Korean Medical Association, 2014
고혈압은 다양한 병인을 가진 질환이다. 젊어서는 교감 신경계 또는 레닌-안지오텐신계 활성이 고혈압 발생의 주 기전이고, 그리고 나이가 들어서는 소금 및 볼륨증가가 혈 압상승을 이끄는 주 기전이다. 60여 년 전부터 고혈압 약 제의 개발도 이런 기전에 따라서 베타차단제, 알파차단제, 알파-베타차단제와 같은 교감신경억제제, 체내 소금 및 볼륨을 줄이기 위해 이뇨제와 칼슘채널차단제가 개발되 었고, 안지오텐신수용체차단제 또는 안지오텐신전환효소 억제제와 같은 레닌-안지오텐신계 활성억제제가 개발되 어 성공적으로 사용하고 있고, 최근에는 직접 레닌억제제, 알도스테론 길항제 등이 고혈압 약물로 소개되었다. 최근 에는 우리나라를 비롯하여 여러
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source