Results 231 to 240 of about 943,135 (348)

Prediction of cancer cell line-specific synergistic drug combinations based on multi-omics data. [PDF]

PeerJ
Chen J, Han H, Li L, Chen Z, Liu X, Li T, Wang X, Wang Q, Zhang R, Feng D, Yu L, Li X, Wang L, Li B, Li J.   +14 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS [PDF]

, 2008
Gordon Gilbert, Ying Kuen Cheung, Bruce Levin, Howard Andrews, Carolyn Doorish, Robert B. MacArthur, Jacqueline Montes, Kate Bednarz, Julaine Florence, Julie Rowin, Khrista Boylan, Tahseen Mozaffar, Rup Tandan, Hiroshi Mitsumoto, Elizabeth A. Kelvin, John Chapin, Richard Bedlack, Michael H. Rivner, Leo McCluskey, Alan Pestronk, Michael C. Graves, Eric J. Sorenson, Richard J. Barohn, Jerry M. Belsh, Jau-Shin Lou, Todd Levine, David Saperstein, Robert G. Miller, Stephen N. Scelsa, The Combination Drug Selection Tria   +29 more
openalex   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

A landscape of response to drug combinations in non-small cell lung cancer. [PDF]

Nat Commun, 2023
Nair NU, Greninger P, Zhang X, Friedman AA, Amzallag A, Cortez E, Sahu AD, Lee JS, Dastur A, Egan RK, Murchie E, Ceribelli M, Crowther GS, Beck E, McClanaghan J, Klump-Thomas C, Boisvert JL, Damon LJ, Wilson KM, Ho J, Tam A, McKnight C, Michael S, Itkin Z, Garnett MJ, Engelman JA, Haber DA, Thomas CJ, Ruppin E, Benes CH.   +29 more
europepmc   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. [PDF]

PLoS One
Zhou M, Xu M, Zhang X, Xing X, Li Y, Wang G, Yan G.   +6 more
europepmc   +1 more source

CRISPR-Cas System Is an Effective Tool for Identifying Drug Combinations That Provide Synergistic Therapeutic Potential in Cancers. [PDF]

Cells, 2023
Kim Y, Lee HM.
europepmc   +1 more source

In vitro Chemosensitivity of Hepatocellular Carcinoma for Hepatic Arterial Infusion Chemotherapy Using the MTT Assay with the Combinations of Antitumor Drugs

, 2004
Satoshi Furukawa
openalex   +2 more sources

HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations [PDF]

, 2009
César Garriga, Marı́a Jesús Pérez-Elı́as, Rafaël Delgado, Lı́dia Ruiz, Lucía Pérez-Álvarez, Tomàs Pumarola, A. López-Lirola, Juan González‐García, Luis Menéndez‐Arias   +8 more
openalex   +1 more source