The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer. [PDF]
Adewale OO+3 more
europepmc +1 more source
Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98 [PDF]
Phillip O. Coffin+5 more
openalex
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells [PDF]
Ralph Zinner+13 more
openalex +1 more source
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa+13 more
wiley +1 more source
iDOMO: identification of drug combinations via multi-set operations for treating diseases. [PDF]
Zhou X, Wu L, Wang M, Wu G, Zhang B.
europepmc +1 more source
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki+11 more
wiley +1 more source
DD-PRiSM: a deep learning framework for decomposition and prediction of synergistic drug combinations. [PDF]
Jin I, Lee S, Schmuhalek M, Nam H.
europepmc +1 more source
Melding a New 3-Dimensional Agarose Colony Assay with the EmaxModel to Determine the Effects of Drug Combinations on Cancer Cells [PDF]
Yoshinori Kajiwara+5 more
openalex +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng+13 more
wiley +1 more source