Results 81 to 90 of about 769,426 (246)

Publisher Correction: Network-based prediction of drug combinations

Nature Communications, 2019
The original version of this Article contained an error in Acknowledgements, which incorrectly omitted the following: ‘This work was also supported by NHLBI grant P01HL132825 to A.-L.B.’ This has been corrected in both the PDF and HTML versions of the ...
Feixiong Cheng, István A. Kovács, Albert-László Barabási   +2 more
doaj   +1 more source

Characterizing genomic alterations in cancer by complementary functional associations. [PDF]

, 2016
Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain ...
A Azzalini, A Kraskov, A Kraskov, A Singh, A Young, AA Margolin, AJ Butte, Amir Reza Alizad-Rahvar, Andrew Aguirre, Arthur Liberzon, Aviad Tsherniak, B Luo, Barbara A Weir, C Ding, C Scholl, CA Miller, CD Correa, Chet Birger, Chiara Romualdi, CJ Vaske, Cory M Johannessen, D Feng, D Guardavaccaro, D Malhotra, D Nijhawan, D Pandey, DA Barbie, Daniel DiCara, David A Barbie, David J Konieczkowski, DD Shao, Diane D Shao, DP Hollern, DP Minde, DV Foster, EH Linfoot, Eliezer M Van Allen, F Vandin, F Vandin, Francisca Vazquez, G Ciriello, GA Darbellay, Gabriela Alexe, Gabriele Sales, Gad Getz, GM DeNicola, H Joe, H Peng, H Zou, Heidi Greulich, HW Cheung, J Barretina, J Lin, J Rosenbluh, JA McCubrey, Jesse S Boehm, Jill P Mesirov, JN Weinstein, Jong Wook Kim, Joseph Rosenbluh, JP Brunet, JS Boehm, L Chin, L Chin, L Waldron, Levi A Garraway, LM Solis, M Meyerson, Mahmoud Ghandi, Masoud Ardakani, MB Raeder, MD Leiserson, ME Abazeed, Michael Noble, Mohamed E Abazeed, MS Lawrence, MS Lawrence, Olga B Botvinnik, Omar Abudayyeh, P Tamayo, Pablo Tamayo, Peter S Hammerman, R Beroukhim, R Firestein, R Steuer, Rameen Beroukhim, S Pendyala, S Sheather, SS Brar, T Valenta, Travis I Zack, William C Hahn, Y Gu, Yashaswi Shrestha   +93 more
core   +1 more source

An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors [PDF]

, 2014
Current anticancer chemotherapy relies on a limited set of in vitro or indirect prognostic markers of tumor response to available drugs. A more accurate analysis of drug sensitivity would involve studying tumor response in vivo.
Baselga, Jose, Cima, Michael J., Fuller, Jason E., Jonas, Oliver H., Landry, Heather M., Langer, Robert S, Santini, John T., Jr., Tepper, Robert I.   +7 more
core   +1 more source

Assessment of knowledge, attitude and practice of fixed-dose combinations amongst attending physicians and residents: a cross-sectional evaluation

Drugs in Context
Background: Fixed-dose combinations (FDCs) were brought into the market with the intent of providing benefits primarily to patients and physicians.
Dhyuti Gupta, Prithpal Singh Matreja, Shilpa Patrick, Meenu Thomas, Pooja Agarwal, Preeti Singh   +5 more
doaj   +1 more source

Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors

Chinese Journal of Lung Cancer, 2020
Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure ...
Pan WANG, Honglin ZHAO, Fan REN, Qingchun ZHAO, Ruifeng SHI, Xingyu LIU, Jinghao LIU, Yongwen LI, Ying LI, Hongyu LIU, Jun CHEN   +10 more
doaj   +1 more source

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar, Klose, Christina, Kouyaté, Bocar, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Sié, Ali, Walter-Sack, Ingeborg, Zoungrana, Augustin   +10 more
core   +1 more source

Natural product based anticancer drug combination discovery assisted by deep learning and network analysis

Frontiers in Natural Products
Drug combination therapies have shown effective performance in treating cancer through increased efficacy and circumvention of drug resistance through synergy.
Elton L. Cao
doaj   +1 more source

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer. [PDF]

, 2015
Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique
Berndsen, R.H., Dallinga, M., Ding, X., Dormond, O., Dyson, P.J., Griffioen, A.W., Ho, C.M., Nowak-Sliwinska, P., Pili, R., Schlingemann, R.O., Shen, L., van Beijnum, J.R., van den Bergh, H., Weiss, A., Wong, I., Wong, T.J.   +15 more
core   +4 more sources

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains.

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, Ipemida S, Fivelman, Quinton L, Warhurst, David C   +2 more
core   +2 more sources

Indomethacin-Enhanced Anticancer Effect of Arsenic Trioxide in A549 Cell Line: Involvement of Apoptosis and Phospho-ERK and p38 MAPK Pathways [PDF]

, 2013
Background. Focusing on novel drug combinations that target different pathways especially apoptosis and MAPK could be a rationaleforcombinationtherapyinsuccessfultreatmentoflungcancer.Concurrentuseofcyclooxygenase(COX)inhibitorswith arsenictrioxide(ATO ...
Amirheidari, Bagher, Ghahremani, MohammadHossein, Mandegary, Ali, Seyedabadi, Mohammad, Sharif, Elham, Torshabi, Maryam   +5 more
core   +2 more sources