Results 81 to 90 of about 943,135 (348)
SynergyFinder : a web application for analyzing drug combination dose-response matrix data [PDF]
, 2017 Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the preclinical significance of pairwise drug combinations, functional screening ...
Al-Lazikani +14 more
core +1 more source
Rational Combinations of Targeted Therapy and Immune Checkpoint Inhibitors in Head and Neck Cancers
Frontiers in Oncology, 2022 Immunotherapy, especially the immune checkpoint inhibitors (ICIs) such as the pembrolizumab and nivolumab have contributed to significant improvements in treatment outcomes and survival of head and neck cancer (HNC) patients.
Annie Wai Yeeng Chai +3 more
doaj +1 more source
Deep Graph Convolutional Network and LSTM based approach for predicting drug-target binding affinity [PDF]
arXiv, 2022 Development of new drugs is an expensive and time-consuming process. Due to the world-wide SARS-CoV-2 outbreak, it is essential that new drugs for SARS-CoV-2 are developed as soon as possible. Drug repurposing techniques can reduce the time span needed to develop new drugs by probing the list of existing FDA-approved drugs and their properties to reuse
arxiv
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Changes in kidney function in a population with essential hypertension in real life settings [PDF]
, 2017 Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a ...
Haidich, Anna-Bettina +6 more
core
Systematic Identification of Synergistic Drug Pairs Targeting HIV [PDF]
, 2013 The systematic identification of effective drug combinations has been hindered by the unavailability of methods that can explore the large combinatorial search space of drug interactions.
Elledge, Stephen J. +9 more
core +1 more source
Guided screen for synergistic three-drug combinations.
PLoS ONE, 2020 Combinations of three or more drugs are routinely used in various medical fields such as clinical oncology and infectious diseases to prevent resistance or to achieve synergistic therapeutic benefits.
Melike Cokol-Cakmak +4 more
doaj +1 more source
FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source
Availability and affordability of treatment for Human African Trypanosomiasis. [PDF]
, 2001 Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance.
Etchegorry, M +4 more
core +3 more sources
Drug-drug interaction prediction based on co-medication patterns and graph matching [PDF]
arXiv, 2019 Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are developed within support vector machines for the prediction.
arxiv