Results 101 to 110 of about 212,176 (310)
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Pilot study : External surface contamination of gemcitabine and 5-fluorouracil on drug packaging
Introduction: Antineoplastic drugs (ADs) are commonly used pharmaceuticals for anticancer treatments. It has previously been shown that the external surface of drug vials frequently is contaminated with ADs.
Wetterling, Maria +4 more
core +2 more sources
Journal of Pharmaceutical and Biomedical Analysis OpenN-nitrosamines have been a concern for decades due to their potential mutagenicity and widespread occurrence across various matrices. While evidence suggests carcinogenicity in animals, their potential carcinogenicity in humans has prompted their initial
Yue Zhang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Проблемы особо опасных инфекций, 2016 Nowadays, problem of tableted drug form contamination with extraneous micro-flora is in the spotlight of scientists, as the specific share of these medical preparations in the world market amounts to more than 60 % and has a tendency to increase.
A. S. Tumanov +11 more
doaj +1 more source
Side-by-Side Comparison of Methods for Environmental Monitoring for Hazardous Drug Contamination. [PDF]
Can J Hosp Pharm, 2023 Hon CY.
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
, 2014 We previously reported that antineoplastic drug contamination is found on various work surfaces situated throughout the hospital medication system (process flow of drug within a facility from initial delivery to waste disposal).
Venners, Scott +3 more
core +1 more source
Антибиотики и Химиотерапия, 2020 Ingavirin® is low toxic for the MDCK cell culture. The drug concentration of 1000 mcg/ml does not reach the CD50 value. The antiviral activity of Ingavirin® was studied with respect to the influenza virus A/H1N1, including the Remantadin® resistant ...
G. A. Galegov +2 more
doaj
Impurities in Drug Vials Intended for Intravitreal Medication
Case Reports in Ophthalmological Medicine, 2020 Sterility is an important prerequisite for minimizing the risk of severe vision loss due to endophthalmitis after intravitreal injections. We describe three cases series of incidents where an unclear contamination of the drug solution or syringe caused ...
Lisa Pohl +3 more
doaj +1 more source