Results 191 to 200 of about 4,579,977 (389)

N-nitrosamine risk assessment in pharmaceuticals: Where are we from a regulatory point of view in 2025?

open access: yesJournal of Pharmaceutical and Biomedical Analysis Open
N-nitrosamines have been a concern for decades due to their potential mutagenicity and widespread occurrence across various matrices. While evidence suggests carcinogenicity in animals, their potential carcinogenicity in humans has prompted their initial
Yue Zhang   +4 more
doaj  

Embedded 3D‐Coaxial Bioprinting of Stenotic Brain Vessels with a Mechanically Enhanced Extracellular Matrix Bioink for Investigating Hemodynamic Force‐Induced Endothelial Responses

open access: yesAdvanced Functional Materials, EarlyView.
In this study, a physically enhanced vascular dECM bioink and used 3D‐coaxial bioprinting are developed to fabricate mature brain blood vessels for cerebral atherosclerosis research. This model demonstrates that vascular geometry‐induced hemodynamic changes trigger vascular inflammation, ensuring its potential for cerebrovascular research.
Wonbin Park   +7 more
wiley   +1 more source

The effect of bambermycin, carbadox, chlortetracycline and olaquindox on antibiotic resistance in intestinal coliforms: a new animal model [PDF]

open access: yes, 1984
Groups of germ-free mice kept in isolators and associated with faecal microflora from piglets were continuously given either water or a solution of one of the following: chlortetracycline (20 micrograms/ml), carbadox (50 micrograms/ml), olaquindox (50 ...
Corpet, Denis E.
core   +1 more source

Bacteremia caused by contaminated intravenous drip drug

open access: yesJournal of Microbiology, Immunology and Infection, 2015
Ying-shih Su   +2 more
openaire   +2 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

open access: yesAdvanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson   +12 more
wiley   +1 more source

A Sustainable Biotechnology Approach for Mineral Separation

open access: yesAdvanced Functional Materials, EarlyView.
Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang   +7 more
wiley   +1 more source

Ultrahigh‐resolution (λ/10) Femtosecond Laser Writing of Polymer‐Encapsulated Multicolor Perovskite Patterns Beyond the Diffraction Limit

open access: yesAdvanced Functional Materials, EarlyView.
Fabrication of in situ polymer‐encapsulated stable perovskite patterns of arbitrary shapes and pixel arrays with a resolution of 80 nm is reported by the femtosecond (fs) laser (800 nm) super‐resolution writing technique. The two‐photon absorption‐induced laser ablation is attributed to the achieved feature sizes as small as λ/10.
Xuebing Wen   +8 more
wiley   +1 more source

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