Results 51 to 60 of about 206,682 (263)

Contamination of a drug consumption room with drugs and potential risks for social health care workers

Harm Reduction Journal
Background Studies have shown that contamination of surfaces by illicit drugs frequently occurs in forensic laboratories when manipulating seized samples as well as in pharmacies and hospitals when preparing medicinal drugs.
Flore Cuffaro, Georges Dahm, Claude Marson, Patrick Berlemont, Michel Yegles, Claudia Allar, Lionel Fauchet, Matteo Creta, Serge Schneider   +8 more
doaj   +1 more source

Microbiological Contamination of Nasal Topical Preparations Used After Septoplasty: A Comparative Analysis

Medeniyet Medical Journal
Objective: The aim of this study was to evaluate the microbiological contamination rates of nasal topical preparations (sprays, drops, and ointments) used after septoplasty at the nozzle/tube tip and drug content levels.
Numan KOKTEN, Zafer HABIP, Berina SLIPCEVIC, Mustafa HATIPOGLU, Zeynep AZ AYDIN, Batın Berkay OZNACAR, Serdal CELIK, M. Tayyar KALCIOGLU   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Simian virus 40, poliovirus vaccines, and human cancer: research progress versus media and public interests

Bulletin of the World Health Organization, 2000
From 1955 through early 1963, millions of people were inadvertently exposed to simian virus 40 (SV40) as a contaminant of poliovirus vaccines; the virus had been present in the monkey kidney cultures used to prepare the vaccines and had escaped detection.
J.S. Butel
doaj  

Nitrosamine contamination of pharmaceuticals: Cases in Japan, formation mechanisms, detection methods, regulatory perspectives, and insights

Journal of Pharmaceutical and Biomedical Analysis Open
In recent years, mutagenic nitrosamines, such as N-nitrosodimethylamine, have been detected in medicine. This has led to global product recalls and long-term supply suspensions by pharmaceutical companies and consequent clinical impacts.
Genichiro Tsuji, Hidetomo Yokoo, Yosuke Demizu, Yasuhiro Abe, Sayaka Masada, Nahoko Uchiyama, Tomoaki Tsutsumi, Eiichi Yamamoto   +7 more
doaj   +1 more source

Assessment of Milk Contamination, Associated Risk Factors, and Drug Sensitivity Patterns among Isolated Bacteria from Raw Milk of Borena Zone, Ethiopia

Journal of Tropical Medicine, 2022
Background. The contamination of raw milk depends on the number and type of organisms that can cause health risks, which can be judged by the presence of microorganisms and bacterial pathogens.
Alqeer Aliyo, Zelalem Teklemariam
doaj   +1 more source

Environmental Contamination with Hazardous Drugs in Quebec Hospitals

The Canadian Journal of Hospital Pharmacy, 2012
Since publication of the US National Institute for Occupational Safety and Health alert on hazardous drugs in 2004, many health care organizations have reviewed their procedures for handling hazardous drugs. Occupational exposure may occur when handling, compounding, or administering a drug considered to be hazardous, at any stage from storage to waste
Jean-François, Bussières, Cynthia, Tanguay, Karine, Touzin, Eric, Langlois, Michel, Lefebvre   +4 more
openaire   +3 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Impact of a Probiotic-Based Cleaning Intervention on the Microbiota Ecosystem of the Hospital Surfaces: Focus on the Resistome Remodulation. [PDF]

PLoS ONE, 2016
Contamination of hospital surfaces by clinically-relevant pathogens represents a major concern in healthcare facilities, due to its impact on transmission of healthcare-associated infections (HAIs) and to the growing drug resistance of HAI-associated ...
Elisabetta Caselli, Maria D'Accolti, Alberta Vandini, Luca Lanzoni, Maria Teresa Camerada, Maddalena Coccagna, Alessio Branchini, Paola Antonioli, Pier Giorgio Balboni, Dario Di Luca, Sante Mazzacane   +10 more
doaj   +1 more source