Results 71 to 80 of about 2,428,128 (309)

Assessment of Milk Contamination, Associated Risk Factors, and Drug Sensitivity Patterns among Isolated Bacteria from Raw Milk of Borena Zone, Ethiopia

Journal of Tropical Medicine, 2022
Background. The contamination of raw milk depends on the number and type of organisms that can cause health risks, which can be judged by the presence of microorganisms and bacterial pathogens.
Alqeer Aliyo, Zelalem Teklemariam
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Decriminalisation of drug use and possession in Australia – A briefing note. [PDF]

, 2016
Currently there is debate about how Australia could better respond to illegal drugs and the associated harm. One frequently raised option is “decriminalisation of drug use and possession”.
Barratt, M, Moxham-Hall, V, Hughes, C ; https://orcid.org/, Barratt, M ; https://orcid.org/, Chalmers, J, Ritter, A ; https://orcid.org/, Hughes, C, Ritter, A, Lancaster, K ; https://orcid.org/, Lancaster, K, Moxham-Hall, V ; https://orcid.org/   +10 more
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Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Impact of a Probiotic-Based Cleaning Intervention on the Microbiota Ecosystem of the Hospital Surfaces: Focus on the Resistome Remodulation. [PDF]

PLoS ONE, 2016
Contamination of hospital surfaces by clinically-relevant pathogens represents a major concern in healthcare facilities, due to its impact on transmission of healthcare-associated infections (HAIs) and to the growing drug resistance of HAI-associated ...
Elisabetta Caselli, Maria D'Accolti, Alberta Vandini, Luca Lanzoni, Maria Teresa Camerada, Maddalena Coccagna, Alessio Branchini, Paola Antonioli, Pier Giorgio Balboni, Dario Di Luca, Sante Mazzacane   +10 more
doaj   +1 more source

Taking stock: A decade of drug policy - A civil society shadow report. [PDF]

, 2018
Taking stock: A decade of drug policy’ evaluates the impacts of drug policies implemented across the world over the past decade, using data from the United Nations (UN), complemented with peer-reviewed academic research and grey literature reports from ...

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Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Self-reported pathways through which illicitly manufactured fentanyl enters the stimulant supply: Novel insights from people incarcerated for drug manufacturing and distribution

SSM: Qualitative Research in Health
Background: The unintentional consumption of stimulants containing fentanyl among people who intend to only use stimulants contributes to overdose mortality in North America.
Patrick J.A. Kelly, Stephanie A. Vento, Traci C. Green, Josiah D. Rich, Madeline Noh, Joseph Silcox, Jaclyn M.W. Hughto   +6 more
doaj   +1 more source

Environmental contamination : a selection of papers presented at the 5th International Conference on Environmental Contamination, Morges, Switzerland, 29 September-1 October 1992 /

, 1993
This book deals with various aspects of environmental contamination. One of the fields considered in this work is atmospheric pollution. This has become a major problem of our time, and could soon develop into a scandal through the overestimation of the ...
Vernet, J.-P.(Jean-Pierre), International Conference on Environmental Contamination(5th :1992 :Morges, Switzerland)   +1 more
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