Results 31 to 40 of about 7,294 (204)

Biologics vs. small molecules: Drug costs and patient access

Medicine in Drug Discovery, 2021
Significant advances in drug research and development are herein reviewed first to set the background for a critical consideration of the economic sustainability of biologics and small molecules, why biologic drugs are more expensive, and how drug cost ...
Favour Danladi Makurvet
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Socioeconomic and Cost Analysis of Off‐Label Nebulized Ciprofloxacin‐Dexamethasone Use Following Airway Surgery

OTO Open
Objective Nebulized ciprofloxacin‐dexamethasone (CPD) is an adjuvant, off‐label treatment used to optimize healing after airway surgery, but there is limited data regarding its accessibility.
Abbey L. Landini, Cyrus W. Abrahamson, Jonathan P. Kuriakose, Jasmine Stewart, James A. Burns, Andrew P. Stein   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Referral Burden and Cost of Outpatient Care of Patients Covered by the Rural Insurance Fund before and after the Implementation of Electronic Referral System in Golestan Province

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2021
Background: Part of the major health costs is related to outpatient care. Since the costs of diagnosis and treatment are increasing rapidly and increasingly, this study was conducted to determine the referral burden and cost of outpatient care of ...
Anis Abbasi, Mohammad Javad Kabir, Fatemeh Kavian Telouri, Alireza Heidari, Zahra Khatirnamani, Narges Rafiei, Anahita Keshavarzi   +6 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Anticancer drugs approved by the Food and Drug Administration for gastrointestinal malignancies: Clinical benefit and price considerations

Cancer Medicine, 2019
Background The cost of new anticancer drugs is rising. We aimed to assess the clinical benefit and price of anti‐cancer drugs approved by the US Food and Drug Administration (FDA) for advanced gastrointestinal cancers. Methods Drugs approved between 2006
Di Maria Jiang, Kelvin K. W. Chan, Raymond W. Jang, Christopher Booth, Geoffrey Liu, Eitan Amir, Robert Mason, Louis Everest, Elena Elimova   +8 more
doaj   +1 more source

The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania

Malaria Journal, 2008
Background The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Abdulla Salim, Mchomvu Naiman, Munkondya John S, Mulligan Jo, Kachur S Patrick, Goodman Catherine A, Njau Joseph D, Bloland Peter, Mills Anne   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Urologic Cancer Drug Costs in Low- and Middle-Income Countries

Société Internationale d’Urologie Journal
All 189 World Bank member countries are classified by their capita gross national income into one of four income groups. In this review, we aim to explore the economic burden and management of urologic oncology conditions in low- and middle-income ...
Lan Anh S. Galloway, Brian D. Cortese, Ruchika Talwar   +2 more
doaj   +1 more source