Results 41 to 50 of about 7,294 (204)

The direct costs of drug-induced skin reactions

Annals of Agricultural and Environmental Medicine, 2017
Objective The aim of the study was an assessment of direct costs of patients hospitalised for for skin adverse drug reactions during 2002–2012 in the Department of Dermatology at the Military Institute of Medicine (Ministry of Defence) in Warsaw.
Nina Kiepurska, Elwira Paluchowska, Witold Owczarek, Monika Szkultecka – Dębek, Karina Jahnz-Różyk   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

OECD Ülkelerinde İlaç Harcamalarının Belirleyicileri

Turkish Academic Research Review
İlaç harcamaları, 1970’ten bu yana GSYİH’nin payı olarak istikrarlı bir şekilde artmaktadır. Bununla birlikte, toplam sağlık harcamaları da artmıştır.
İsmail Biçer
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Promoting adverse drug reaction reporting: comparison of different approaches

Revista de Saúde Pública, 2016
OBJECTIVE To describe different approaches to promote adverse drug reaction reporting among health care professionals, determining their cost-effectiveness.
Inês Ribeiro-Vaz, Cristina Costa Santos, Ricardo Cruz-Correia   +2 more
doaj   +1 more source

National mass drug administration costs for lymphatic filariasis elimination. [PDF]

PLoS Neglected Tropical Diseases, 2007
BACKGROUND: Because lymphatic filariasis (LF) elimination efforts are hampered by a dearth of economic information about the cost of mass drug administration (MDA) programs (using either albendazole with diethylcarbamazine [DEC] or albendazole with ...
Ann S Goldman, Victoria H Guisinger, Moses Aikins, Maria Lourdes E Amarillo, Vicente Y Belizario, Bertha Garshong, John Gyapong, Conrad Kabali, Hussein A Kamal, Sanjat Kanjilal, Dominique Kyelem, Jefrey Lizardo, Mwele Malecela, Godfrey Mubyazi, P Abdoulaye Nitièma, Reda M R Ramzy, Thomas G Streit, Aaron Wallace, Molly A Brady, Richard Rheingans, Eric A Ottesen, Anne C Haddix   +21 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Costs of mass drug administration for scabies in Fiji.

PLoS Neglected Tropical Diseases, 2022
In 2019, the Murdoch Children's Research Institute in partnership with the Fiji Ministry of Health and Medical Services carried out an integrated mass drug administration (MDA) for the treatment of scabies and lymphatic filariasis in the Northern ...
Maria Mow, Li Jun Thean, Matthew Parnaby, Jyotishna Mani, Eric Rafai, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Lucia Romani, Daniel Engelman, Margot Whitfeld, John Kaldor, Andrew Steer, Natalie Carvalho   +14 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source