Results 31 to 40 of about 238,633 (312)

Reducing Drug Plant Cultivation to a Science [PDF]

Scientific American, 1917
n ...
openaire   +1 more source

Drugs research: an overview of evidence and questions for policy [PDF]

, 2010
In 2001 the Joseph Rowntree Foundation embarked upon a programme of research that explored the problem of illicit drugs in the UK. The research addressed many questions that were often too sensitive for the government to tackle.
Lloyd, C., McKeganey, N.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Electrochemical Behavior and Direct Quantitative Determination of Paclitaxel

Frontiers in Chemistry, 2022
The electrochemical behavior and direct quantitative determination of paclitaxel, a poorly soluble drug made into microemulsion, were researched by cyclic voltammetry in acetate buffer solutions (pH = 4.0) at a glassy carbon electrode.
Jiaqi Lang, Wenting Wang, You Zhou, Dongqin Guo, Rujie Shi, Nong Zhou   +5 more
doaj   +1 more source

Conservation in conflict: Illegal drugs versus habitat in the Americas [PDF]

, 2008
About the book: State of the Wild is a biennial series that brings together international conservation experts and writers to discuss emerging issues in the conservation of wildlife and wild places.
Bejarano, Adriana C., Dávalos, Liliana M.   +1 more
core  

A Competitive Co-cultivation Assay for Cancer Drug Specificity Evaluation

SLAS Discovery, 2011
The identification of compounds that specifically inhibit or kill cancer cells without affecting cells from healthy tissues is very challenging but very important for reducing the side effects of current cancer therapies. Hence, there is an urgent need for improved assays allowing the selectivity of a given compound to be monitored directly.
Bachir W, El Debs, Ulrich, Tschulena, Andrew D, Griffiths, Christoph A, Merten   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Metabolomic and Pharmacologic Insights of Aerial and Underground Parts of Glycyrrhiza uralensis Fisch. ex DC. for Maximum Utilization of Medicinal Resources

Frontiers in Pharmacology, 2021
The roots of Glycyrrhiza spp. have been utilized in Traditional Chinese medicine (TCM) for thousands of years. Non-traditional (aerial) parts constitute a large portion of the biomass of Glycyrrhiza plants and are mostly discarded after harvesting the ...
Liang Jiang, Waheed Akram, Waheed Akram, Waheed Akram, Biaobiao Luo, Biaobiao Luo, Biaobiao Luo, Sheng Hu, Mohammad Omar Faruque, Shakeel Ahmad, Shakeel Ahmad, Shakeel Ahmad, Nasim Ahmad Yasin, Waheed Ullah Khan, Aqeel Ahmad, Aqeel Ahmad, Aqeel Ahmad, Alexander N. Shikov, Jian Chen, Xuebo Hu, Xuebo Hu, Xuebo Hu   +21 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]

, 2017
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica, Graf, Fabrice E., Kunz Renggli, Christina, Mäser, Pascal, Ndomba, Emiliana, Schmidt, Remo S., Wenzler, Tanja, Wiedemar, Natalie, Zwyer, Michaela   +8 more
core   +3 more sources