Results 41 to 50 of about 238,633 (312)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Social Reality of Depression: DTC Advertising of Antidepressants and Perceptions of the Prevalence and Lifetime Risk of Depression [PDF]
, 2008 This study is rooted in the research traditions of cultivation theory, construct accessibility, and availability heuristic. Based on a survey with 221 subjects, this study finds that familiarity with direct-to-consumer (DTC) print advertisements for ...
Grow, Jean M., Seong Park, Jin
core +1 more source
, 2010 African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER +10 more
core +4 more sources
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Revista UNISCI, 2018 In Afghanistan, opium cultivation was part of an economy of survival in the decades preceding the Afghan resistance war against the Soviets and, during the subsequent civil war, cultivation and trafficking of opium poppy became one of the main methods of
Francisco Berenguer-López
doaj +1 more source
High Time for Conservation: Adding the Environment to the Debate on Marijuana Liberalization [PDF]
, 2015 The liberalization of marijuana policies, including the legalization of medical and recreational marijuana, is sweeping the United States and other countries.
Anne G. Short Gianotti +7 more
core
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Nature CommunicationsEpitranscriptomic modifications, particularly N6-methyladenosine (m6A), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation.
Chuwei Liu +12 more
doaj +1 more source
Rapid Discovery of Antioxidants in Rosa rugosa by UHPLC-PDA-Q-TOF/MS-TACD Integrated Technique
AnalyticaIn this study, an integrated analytical method coupling ultra-high-performance liquid chromatography–photodiode array detection–quadrupole time-of-flight mass spectrometry with total antioxidant capacity determination (UHPLC-PDA-Q-TOF/MS-TACD) was ...
Huijun Wang +4 more
doaj +1 more source