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Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. [PDF]
Genes Brain Behav, 2019 Genetic influences on alcohol and drug dependence partially overlap, however, specific loci underlying this overlap remain unclear. We conducted a genome-wide association study (GWAS) of a phenotype representing alcohol or illicit drug dependence (ANYDEP)
Wetherill L +23 more
europepmc +7 more sources
Astrocytes: the neglected stars in the central nervous system and drug addiction
Medical Review, 2022 With the advent of improved tools to examine the astrocytes, which have been believed to play a supportive role in the central nervous system (CNS) for years, their participation in the operation of the CNS and drug addiction was unveiled.
Chen Wenjun +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Persistent and stable drug memories lead to a high rate of relapse among addicts. A number of studies have found that intervention in addiction-related memories can effectively prevent relapse.
Libo Zhang +13 more
doaj +1 more source
Drug Dependence: Drug Addiction, Drug Abuse, Drug Tolerance and Dependence
International Journal of Advanced Research in Science, Communication and Technology, 2023 Dependence means that when a person stops using a drug, their body goes through “withdrawal”: a group of physical and mental symptoms that can range from mild (if the drug is caffeine) to life-threatening (such as alcohol or opioids, including heroin and prescription pain relievers).
null Mrudula Shrikrishna Pachpande +1 more
openaire +1 more source
Current Concepts on Drug Abuse and Dependence [PDF]
, 2015 Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza +5 more
core +7 more sources
Novel role of AMPK in cocaine reinforcement via regulating CRTC1
Translational Psychiatry, 2022 Repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs.
Xiao-Xing Liu +11 more
doaj +1 more source
Journal of Analytical Science and Technology, 2021 Urinary ethyl glucuronide (EtG), an alcohol biomarker, plays an essential role in monitoring alcohol abstinence and relapse during treatment for alcohol dependence.
Shayani Ghosh +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Social interaction plays an essential role in species survival for socialized animals. Previous studies have shown that a lack of social interaction such as social isolation, especially in the early-life phase, increases the risk of developing mental ...
Xiao Wu +8 more
doaj +1 more source
BMC Geriatrics, 2023 Background The health outcomes of geriatric patients exposed to surgery were found to be enhanced by social support and stress management. The aim of this study was to characterise the relationship between oxytocin and neuropsychiatric disorders after ...
Wanru Dong +6 more
doaj +1 more source
Trends and correlates of substance use disorders among probationers and parolees in the United States 2002–2014 [PDF]
, 2016 BACKGROUND: Substance use and crime/recidivism are irrevocably linked. We explore the nuances of this association by highlighting the prevalence, trends, and correlates of substance use dsorders in a large group of probationers/parolees.
DeLisi, Matt +5 more
core +1 more source