Results 121 to 130 of about 3,052,037 (266)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Drugs of dependence: The role of medical professionals. [PDF]

, 2013
Executive summary • Chapter 1 - Introduction • Chapter 2 - The scale of the problem: illicit drug use in the UK • Chapter 3 - The burden of illicit drug use • Chapter 4 - Influences on illicit drug use • Chapter 5 - Drug policy in the UK: from ...

core  

Characteristics linked to mortality risk among individuals with drug use disorders enrolled in drug rehabilitation facilities in Japan

PCN Reports
Aim This study evaluated survival rates and examined characteristics associated with mortality among individuals with drug use disorder (DUD) enrolled in drug addiction rehabilitation facilities in Japan. Methods This longitudinal cohort study, conducted
Satomi Mizuno, Takuya Shimane, Satoshi Inoura, Maki Kitamura, Toshihiko Matsumoto   +4 more
doaj   +1 more source

Sex Differences in Profiles and Treatment-Seeking Among Patients Visiting the Drug Dependence Treatment Center at a Psychiatric Hospital in India. [PDF]

Indian J Psychol Med, 2023
Khanra S, Mukherjee A, Munda SK.
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

MicroRNA-132/212 negatively modulates opioid reward by targeting dopamine transporter in the ventral tegmental area

Translational Psychiatry
Addictive drugs, notably opioid drugs, have significant societal implications, yet the cellular and molecular mechanisms underpinning rewarding effects remain largely elusive.
Jie Meng, Zhonghao Li, Yi Zhang, Dajun Zhang, Haiting Liu, Xiangyang Zang, Yaqiong Zhao, Jing Wen, Wei Shu, Xiaoke Nan, Xianchan Li, Yan-Xue Xue, Xiaojian Jia   +12 more
doaj   +1 more source

Latent Tuberculosis Infection in Users of Drug Dependence Care and Follow-up Centers in Barcelona in 2017-2021: A Cross-sectional Descriptive Study. [PDF]

Open Respir Arch, 2023
Prieto García R, Millet JP, Palma D, Barbaglia Navarro MG, Gibert CR, Barcelona CAS Working Group.   +5 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Oral Sensations among Individuals with Illicit Drug Dependence in Rehabilitation Centers: A Cross-Sectional Study. [PDF]

J Pharm Bioallied Sci, 2021
Bhuyan L, Nishat R, Goutham B, Dash KC, Mishra P, Mahapatra N.   +5 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source