Results 111 to 120 of about 3,052,037 (266)

Opioids: risk of dependence and addiction.

, 2020
New UK recommendations following a review of the risks of dependence and addiction associated with prolonged use of opioid medicines (opioids) for non-cancer pain.

core  

Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times

, 2012
Relapse is a persistent problem in the management of addiction. Drug-related cues are powerful instigators of relapse. Impulsive decision making may contribute to relapse through a poorly considered assessment of the consequences of drug use.
Wang, Gui-Bin, Zhang, Xiao-Li, Zhao, Li-Yan, Lu, Lin, Sun, Li-Li, Wu, Ping, Shi, Jie   +6 more
core   +1 more source

Development and Psychometric Properties of the Synthetic Drug Dependence Scale in a Chinese Sample. [PDF]

Front Psychol, 2021
Li MT, Zhang J, Zhang DC, Che QQ, Liu ZL, Yang PW, Luo XW, Cai TS.   +7 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Drug Addiction in China

, 2008
Drug addiction in China began with the importation of Indian opium by the British in the 16th century and brought severe social and health problems. While drug abuse abated following the establishment of People's Republic of China, modernization and
Lin Lu, Lu, Lin, Wang, Xi, Xi Wang
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Psychosocial correlates of depression and anxiety among treatment-seeking individuals with opioid dependence: a cross-sectional study

Frontiers in Psychiatry
Background and aimsOpioid dependence is commonly comorbid with depression and anxiety, which contribute to greater disability and poorer quality of life.
Siddharth Sarkar, Muzafar Pandit, Parvender Singh Negi, Rahul Mathur, Yatan Pal Singh Balhara   +4 more
doaj   +1 more source

Psychological distress in a sample of Moroccan prisoners with drug-dependence. [PDF]

Int J Offender Ther Comp Criminol, 2022
Sfendla A, Martinsson B, Filipovic Y, Senhaji M, Kerekes N.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence. [PDF]

World J Psychiatry, 2022
Polli FS, Kohlmeier KA.
europepmc   +1 more source