Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use. [PDF]
Int J Mol Sci, 2023 Quintanilla ME +11 more
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Neuropsychiatric InvestigationObjective: The study aimed to systematically review and analyze the association of gambling behavior with deficits in attention, memory, learning, verbal fluency, and figural fluency.
Yashita Ahluwalia +4 more
doaj +1 more source
Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts. [PDF]
Med Biol Eng Comput, 2023 Jiang W, Cai L, Wang Z.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Effectiveness of opioid maintenance programs for treating drug dependence in prisons. [PDF]
Rev Esp Sanid Penit, 2023 Roselló-Jordá S +2 more
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2020 INTRODUCTION:Although DSM-IV criteria are widely used in making diagnoses of substance use disorders, gaps exist regarding diagnosis classification, use of dependence criteria, and effects of measurement bias on diagnosis assessment.
Wu, Li-Tzy +7 more
core +1 more source
The impact of REM sleep loss on human brain connectivity
Translational PsychiatryBrain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent. The REM sleep phase has been implicated in coordinating various brain structures and is hypothesized to have potential links to brain ...
Tianqi Di +11 more
doaj +1 more source
Case report on intervention of sedative drug dependence with "simple and quick reconstruction method" in psychological crisis assistance. [PDF]
Medicine (Baltimore), 2023 Liang YQ, Yu BD.
europepmc +1 more source