Results 71 to 80 of about 3,052,037 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Introduction to the College on Problems of Drug Dependence Special Issue: Contemporary Advances in Opioid Neuropharmacology

, 2010
Opioid receptors are critical therapeutic targets for medications development relevant to the treatment of drug dependence and pain. With recent advances in molecular neurobiology, it has become evident that the functional activity of opioid receptors ...
Walsh, Sharon L, Unterwald, Ellen M, Izenwasser, Sari   +2 more
core   +1 more source

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial

Brain Stimulation
Background and objectives: Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective.
Yixuan Song, Yuchen Huang, Qihong Zheng, Xiaoqin Yang, Yang Guo, Yanan Geng, Huixing Gou, Junjie Bu, Tianye Jia, Guangdong Zhou, Lin Lu, Jie Shi, Yan Sun   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement

The Scientific World Journal, 2008
The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking.
Yu Liu, Bernard Le Foll, Yanli Liu, Xi Wang, Lin Lu   +4 more
doaj   +1 more source

Neuroleptic Malignant Syndrome Associated with Lithium Toxicity

Oman Medical Journal, 2016
Neuroleptic Malignant Syndrome (NMS) is an idiosyncratic and potentially life-threatening reaction to neuroleptic drugs. Lithium is a first-line mood stabilizer used in the treatment and prophylaxis of bipolar disorder.
Vaibhav Patil, Rishab Gupta, Rohit Verma, Yatan Pal Singh Balhara   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Role of amygdala in drug memory

, 2013
Drug addiction is a chronic brain disorder with the hallmark of a high rate of relapse to compulsive drug seeking and drug taking even after long-term abstinence.
Shen, Hao-Wei, Xue, Yan-Xue, Lu, Lin, Luo, Yi-Xiao   +3 more
core   +1 more source

Comparing Marital Adjustment in Couples Having Alcohol- or Opioid-dependent Husbands

Indian Journal of Psychological Medicine
Background: Substance use disorder is a complex bio-psycho-social phenomenon affecting the intimate relationship of substance users with their wives. Marital adjustment may be affected due to the ongoing substance use involving the family unit.
Sayani Bisoi, Gauri Shanker Kaloiya, Anju Dhawan, Siddharth Sarkar   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source