Results 51 to 60 of about 3,052,037 (266)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Impulsivity and response inhibition in alcohol dependence and problem gambling [PDF]
, 2009 INTRODUCTION: Impulsivity is a central feature of drug addiction and may arise as a result of impaired inhibitory control. The extent to which inhibitory deficits arise as a consequence of drug exposure or relate to pre-existing addiction vulnerability ...
Lawrence, AJ +14 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
BMC PsychiatryBackground Previous studies demonstrated thyroid stimulating hormone (TSH) plays an important role in regulating lipid metabolism, but the relationship between the two is controversial.
Chun-Qing Cui +9 more
doaj +1 more source
Vaccines to Treat Substance Use Disorders: Current Status and Future Directions
PharmaceuticsAddiction, particularly in relation to psychostimulants and opioids, persists as a global health crisis with profound social and economic ramifications.
Tangsheng Lu +9 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Drug to curb alcohol dependence gets go-ahead.
, 2012 A new drug that treats alcohol dependence by removing a person’s desire to drink is due to be available on prescription in Ireland next year. The European Medicines Agency has recommended approval of Selincro — the first approved drug therapy to ...
Ring, Evelyn
core
WHO Expert Committee on Drug Dependence [meeting held in Geneva from 28 September to 2 October 1992] : twenty-eighth report [PDF]
, 1993 43 p.Evaluates various strategies and approaches for reducing the harm to health and social functioning caused by the use of psychoactive drugs, including alcohol and tobacco.
World Health Organization +1 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Stress reactivity in heroin dependence [PDF]
, 2015 Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core +1 more source