Results 101 to 110 of about 1,782,190 (315)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Drug Design and Drug Discovery

International Journal of Innovative Science and Research Technology (IJISRT)
One of the key forces influencing the advancement of pharmaceuticals, biotechnology, and pharmacology is the drug industry. The process of finding and creating medications is known as drug discovery. It is a procedure designed to find a substance that has therapeutic value in treating and curing illness.
Aditya Maurya, Aditya Tripathi, Afsana Khatoon, Aishwarya Singh, Sandeep Kumar Singh   +4 more
openaire   +1 more source

Modern Multicomponent Reactions for better Drug Syntheses** [PDF]

, 2014
Multicomponent reaction (MCR) technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry as well as academia.
Dömling, Alexander, Alexander Dömling, Zarganes-Tzitzikas, Tryfon, Tryfon Zarganes-Tzitzikas   +3 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cyclic β-(1, 2)-glucan blended poly DL lactic co glycolic acid (PLGA 10:90) nanoparticles for drug delivery

Heliyon, 2019
Our group had previously reported the encapsulation efficiency of cyclic β-(1, 2)-glucan for various drugs. The current study is aimed at evaluating the use of glucan as a drug carrier system by blending with poly lactic-co- glycolic acid (L:G = 10:90 ...
Geetha Venkatachalam, Nandakumar Venkatesan, Ganesan Suresh, Mukesh Doble   +3 more
doaj   +1 more source

Applications of metadynamics to drug design-related issues

, 2007
Applications of metadynamics to drug design-related issues Andrea Cavalli 1Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy The methadynamics method1 is a relatively new molecular dynamics ...
CAVALLI, ANDREA
core  

Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles

, 2016
Albumin-based nanoparticles (NPs) are a promising technology for developing drug-carrier systems, with improved deposition and retention profiles in lungs.
Cui, Wei, Lin, Shao-Hui, Liu, Ying-Chun, Meng, Shuai, Xie, Ying, Jin, Hong-Wei, Wang, Gui-Ling, Zhang, Liang-Ren   +7 more
core   +1 more source

New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools

, 2022
Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the existence of approved drugs
Paola Borrego-Muñoz, Arrué, Lily, Oviedo, Victoria, Martínez-García, Claudia, George E. Barreto, Carlos Peña-Varas, Peña-Varas, Carlos, Borrego-Muñoz, Paola, Lily Arrué, Muñoz, Juana, Márquez Montesinos, José C. E., José C. E. Márquez Montesinos, Juana Muñoz, Barbosa, Tábata, Barreto, George E., Paula A. Santana, González, Janneth, Alexandra Cigna-Méndez, Silvia Struve-Villalobos, Natalia Millán, Ramírez, David, Struve-Villalobos, Silvia, Millán, Natalia, Santana, Paula A., Cigna-Méndez, Alexandra, Claudia Martínez-García, Sepúlveda-Lara, Alexis, Tábata Barbosa, Janneth González, Victoria Oviedo, David Ramírez, Barreto, George, Alexis Sepúlveda-Lara   +32 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Long intergenic non-coding RNA 00511 (LINC00511) genetic variations and haplotype implication for colorectal cancer susceptibility and prognosis

Scientific Reports
Long intergenic non-coding RNA 00,511 (LINC00511) is considered an oncogene for various cancers. However, the association between LINC00511 single nucleotide polymorphisms (SNPs) and colorectal cancer (CRC) remains unclear.
Eman F. Sanad, Ahmad A. Hady, Mohamed Ali, Shorouk Eldash, Nermeen H. Elmorshedy, Farah Ayman, Hams M. Khattab, Amr Maher, Hadeel Ashree, Mahitab Abdelhady, Mazen Mohamed, Ahmed Adel, Sajed Khalil, Omar Alyan, Ahmed Samir, Alhassan A. Bakr, Nadia M. Hamdy   +16 more
doaj   +1 more source