Results 81 to 90 of about 1,790,908 (315)

A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo

Frontiers in Chemistry, 2020
Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications.
Jing Ma, Yingguang Li, Linrong Li, Kexin Yue, Hanfang Liu, Jiajia Wang, Zhuoqing Xi, Zhuoqing Xi, Man Shi, Sihan Zhao, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Lili Hou, Chaojie Wang, Peng George Wang, Zhiyong Tian, Songqiang Xie   +18 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

BMT4me En Español: Multisite Feasibility and Usability Testing of a Spanish‐Language mHealth Adherence Support App for Spanish‐Speaking Caregivers of Children After Hematopoietic Stem Cell Transplantation and Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens, Madeline R. Peek, Bianca Franklin, Emre Sezgin, Melissa Beauchemin   +4 more
wiley   +1 more source

Drug eluting hydrogels design, synthesis and evaluation [PDF]

, 2012
Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting ...
Ahrenstedt, Lage
core  

Molecular Dynamics in Drug Design: New Generations of Compstatin Analogs [PDF]

, 2012
We report the computational and rational design of new generations of potential peptide‐based inhibitors of the complement protein C3 from the compstatin family.
Ronald D. Gorham, Georgios Archontis, Tamamis, Phanourios, Floudas, Christodoulos A, Aliana López de Victoria, Phanourios Tamamis, Meghan L. Bellows-Peterson, Christodoulos A. Floudas, Gorham, Ronald D, Bellows-Peterson, Meghan L, Archontis, Georgios, Dimitrios Morikis, López de Victoria, Aliana, Morikis, Dimitrios, Pierou, Panayiota, Panayiota Pierou   +15 more
core   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

The power of the web in cancer drug discovery and clinical trial design: research without a laboratory? [PDF]

, 2010
The discovery of effective cancer treatments is a key goal for pharmaceutical companies. However, the current costs of bringing a cancer drug to the market in the USA is now estimated at $1 billion per FDA approved drug, with many months of research at ...
Galustian, C, Dalgleish, AG, Christine Galustian, Dalgleish, Angus G, Angus G. Dalgleish, Galustian, Christine   +5 more
core   +1 more source

An efficient, lung-targeted, drug-delivery system to treat asthma via microparticles [PDF]

, 2020
Background: Chronic diseases such as diabetes, asthma, and heart disease are the leading causes of death in developing countries. Public health plays an important role in preventing such diseases to improve individuals’ quality of life.
Mukund, Handral, Anroop, Nair, Pottathil, Shinu, Nagaraja, SreeHarsha, Jagadeesh, Hiremath, Bandar, Al-Dhubiab, Roopashree, Srinivasa, Mahesh, Attimarad, Micheline, Haroun, Venugopala, Katharigatta Narayanaswamy, Chandramouli, Ramnarayanan, Christophe, Tratrat   +11 more
core   +1 more source

Graphene Oxide Foam Supported Titanium(IV): Recoverable Heterogeneous Catalyst for Efficient, Selective Oxidation of Arylalkyl Sulfides to Sulfoxides Under Mild Conditions

Scientific Reports, 2017
An efficient and environmentally friendly method was designed for the oxidation of sulfides to sulfoxides with a recyclable, carbon-skeleton-based heterogeneous catalyst developed by titanium sulfate [Ti(SO4)2] mineralization on the surface of graphene ...
Qinghe Wang, Wenxi Ma, Qiaolin Tong, Guijie Du, Jian Wang, Meng Zhang, Hailun Jiang, Huali Yang, Yongxiang Liu, Maosheng Cheng   +9 more
doaj   +1 more source

A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense

Chinese Medicine, 2019
Background The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants. Methods The structures
Cuicui Jia, Chi Gong, Hong Chen, Jing Pu, Dahong Li, Zhanlin Li, Huiming Hua   +6 more
doaj   +1 more source