Results 61 to 70 of about 3,098,024 (301)

Health Care Opinion Leaders' Views on Medicare Reform [PDF]

, 2009
Presents findings of a survey of experts on Medicare's successes and proposed reforms, including putting payment pilots on a fast track, negotiating drug prices, and creating an advisory council with authority to make payment and benefit design ...
Karen Davis, Kristof Stremikis, Stuart Guterman   +2 more
core  

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery

Nature Communications
Artificial intelligence transforms drug discovery, with phenotype-based approaches emerging as a promising alternative to target-based methods, overcoming limitations like lack of well-defined targets.
Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jingyi Zhou, Kun Wang, Lehan Zhang, Yiming Wen, Jiangshan Shi, Sulin Zhang, Xutong Li, Mingyue Zheng   +11 more
doaj   +1 more source

A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo

Frontiers in Chemistry, 2020
Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications.
Jing Ma, Yingguang Li, Linrong Li, Kexin Yue, Hanfang Liu, Jiajia Wang, Zhuoqing Xi, Zhuoqing Xi, Man Shi, Sihan Zhao, Qi Ma, Sitong Liu, Shudi Guo, Jianing Liu, Lili Hou, Chaojie Wang, Peng George Wang, Zhiyong Tian, Songqiang Xie   +18 more
doaj   +1 more source

Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]

, 2013
Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta, Dallocchio, Roberto, Dessì, Alessandro, Ihm, Simone, Pala, Nicolino, Roggio, Anna Maria, Sechi, Mario, Supuran, Claudiu T., Weber, Rino   +8 more
core  

Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya. [PDF]

, 2015
Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs).
Assefa, Aurenhammer, Bergquist, Birgit Nikolay, Brooker, Brooker, Charles S. Mwandawiro, Chu, de Silva, Edwards, Gunawardena, Hall, Hugh J. W. Sturrock, Jennifer L. Smith, Jimmy Kihara, Jovani, Levecke, Linard, Liya Assefa, McCarthy, Minetti, Mwandawiro, Mwandawiro, Nikolay, Njenga, Olives, Patil, Pullan, Sammy M. Njenga, Simon J. Brooker, Smith, Solomon, Sturrock, Sturrock, Sturrock   +34 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Neurobiology of Disease, 2021
Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen, Sofie K. Christensen, Emil W. Westi, Marta Diaz-delCastillo, Heikki Tanila, Arne Schousboe, Blanca I. Aldana, Helle S. Waagepetersen   +7 more
doaj   +1 more source

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]

, 2016
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello, A Jha, A Leendertse, A Somers, A Somers, A Somers, A Spinewine, A Spinewine, A Spinewine, American Geriatrics Society, B Basger, B Berenguer, B Lund, B Strom, B Tangiisuran, C Lindley, C Naugler, C Rancourt, C Scullin, C Zhan, D Classen, E Hajjar, G Batty, G Ellis, G Onder, G Onder, G Onder, G Onder, H Beijer, H Hamilton, I Eland, J Hanlon, J Hanlon, J Klopotowska, J Lazarou, J Schnipper, J Wolfstadt, K Perehudoff, K Schmader, L Leape, M Beers, M Laroche, M O’Connor, M Passarelli, M Petrovic, M Petrovic, M Pirmohamed, M Steinman, NS Wenger, P Bemt van den, P Gallagher, P Gallagher, P Lampela, P McLeod, P Rochon, R Cipolle, R Page, S Holt, S Kaur, S Kucukarslan, S Rognstad, T Field, T Field, W Winit-Watjana   +63 more
core   +1 more source