Results 61 to 70 of about 1,782,190 (315)

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD3)

, 2023
In an era of unparalleled technical advancement, the pharmaceutical industry is struggling to transform data into increased research and development efficiency, and, as a corollary, new drugs for patients.
Rebecca Racz, David B. Jackson, Keith Burkhart, Stephan Brock, Sarah Kim   +4 more
core   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Thermochemical, spectral and biological activity prediction of some methylpyridine derivatives: a computational approach

Discover Chemistry
Pyridine and its derivatives play a vital role in pharmaceutical and pesticide applications. However, prolonged exposure to pyridine can lead to significant health risks due to its ability to enter the body via inhalation and absorption.
Md. Arifur Rahman, S. M. Mehedi Afnan Rejve, Md. Ruhul Amin Niloy, Mim Afsari, Umma Hany Sawon, Fahima Akter, Rafi Ahmed Miah, Md. Byzed Hasan, Monir Uzzaman   +8 more
doaj   +1 more source

Taking stock: A decade of drug policy - A civil society shadow report. [PDF]

, 2018
Taking stock: A decade of drug policy’ evaluates the impacts of drug policies implemented across the world over the past decade, using data from the United Nations (UN), complemented with peer-reviewed academic research and grey literature reports from ...

core  

Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue

, 2011
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods.
He, Meizi, Tang, Shixing, Tian, Baohe, Ming Yang, Shixing Tang, Shuguang Chen, Chen, Shuguang, Zhiwu Tan, Indira Hewlett, Jin, Yinxue, Yinxue Jin, Meizi He, Yang, Ming, Tan, Zhiwu, Hewlett, Indira, Baohe Tian   +15 more
core   +1 more source

Emerging paradigms in anti-infective drug design. [PDF]

, 2014
The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L, Barrett, Michael P., Barrett, Michael P, Croft, Simon L.   +3 more
core   +1 more source

DrugEx v3: Scaffold-Constrained Drug Design with Graph Transformer-based Reinforcement Learning

, 2021
Due to the large drug-like chemical space available to search for feasible drug-like molecules, rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified. With the rapid growth of the application of
Adriaan P. , IJzerman, Xuhan, Liu, Kai, Ye, Gerard J. P. , van Westen, Herman W. T. , van Vlijmen   +4 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structure-Activity Relationships (SAR) Research of Thiourea Derivatives as Dual Inhibitors Targeting both HIV-1 Capsid and Human Cyclophilin A

, 2010
HIV-1 capsid (CA) and human cyclophilin A (CypA) play important roles in HIV-1 assembly and disassembly processes, which are critical in HIV-1 replication.
He, Meizi, Tang, Shixing, Jin, Yinxue, Yu, Fei, Yang, Ming, Tan, Zhiwu, Hewlett, Indira, Chen, Kan, Li, Jiebo   +8 more
core   +1 more source

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

, 2021
Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide.
Chauhan, Anuj, Butsabarat Klahan, Klahan, Butsabarat, O\u27Reilly, Niall J, Byrne, Mark, Anuj Chauhan, Fitzhenry, Laurence, Burhan, Ayah Mohammad, Andrés-Guerrero, Vanessa, Cummins, Wayne, Hughes, Helen, Helen Hughes, Ayah Mohammad Burhan, Mark E. Byrne, Vanessa Andrés-Guerrero, Wayne Cummins, Laurence Fitzhenry, Niall J. O’Reilly   +17 more
core   +1 more source