Results 131 to 140 of about 2,938,349 (358)

Dynamical model-based experiment design for drug repositioning [PDF]

arXiv
Computational methods in drug repositioning can help to conserve resources. In particular, methods based on biological networks are showing promise. Considering only the network topology and knowledge on drug target genes is not sufficient for quantitative predictions or predictions involving drug combinations.
arxiv  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Longitudinal predictors of weapon involvement in middle adolescence: Evidence from the UK Millennium Cohort Study

Aggressive Behavior, Volume 49, Issue 1, Page 5-14, January 2023., 2023
Abstract This study uses longitudinal data from the UK Millennium Cohort Study (N = 13,277) to examine the childhood and early adolescence factors that predict weapon involvement in middle adolescence, which in this study is exemplified by having carried or used a weapon.
Aase Villadsen, Emla Fitzsimons
wiley   +1 more source

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

Neurobiology of Disease, 2021
Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen, Sofie K. Christensen, Emil W. Westi, Marta Diaz-delCastillo, Heikki Tanila, Arne Schousboe, Blanca I. Aldana, Helle S. Waagepetersen   +7 more
doaj  

Designer drugs and sexual dysfunction [PDF]

Central European Journal of Urology, 2015
New or novel psychoactive substances (NPS) are the most recent forms of designer drugs. These materials are sold as “bath salt” mixtures or fertilizers through the internet and in head shops worldwide [1]. Of course there are no proven medical purpose of these compounds which mostly contain synthetic cathiones or piperazines. The form is usually powder
openaire   +3 more sources

Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]

, 2013
Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta, Dallocchio, Roberto, Dessì, Alessandro, Ihm, Simone, Pala, Nicolino, Roggio, Anna Maria, Sechi, Mario, Supuran, Claudiu T., Weber, Rino   +8 more
core  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Factors modulating 99mTc‐MAA planar lung dosimetry for 90Y radioembolization

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99mTc‐macro‐aggregated albumin (99mTc‐MAA) planar imaging for treatment planning of 90Y‐microsphere radioembolization.
Benjamin P. Lopez, Armeen Mahvash, James P. Long, Marnix G. E. H. Lam, S. Cheenu Kappadath   +4 more
wiley   +1 more source

Exploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation

Scientific Reports
Discovering effective anti-cancer agents poses a formidable challenge given the limited efficacy of current therapeutic modalities against various cancer types due to intrinsic resistance mechanisms.
Nourhan M. Aboomar, Omar Essam, Afnan Hassan, Ahmad R. Bassiouny, Reem K. Arafa   +4 more
doaj   +1 more source

Anti-Cancer Drug Design [PDF]

, 1985
Michael W. Moore
openalex   +1 more source