Results 201 to 210 of about 17,208,238 (361)

hERG toxicity assessment: Useful guidelines for drug design.

European journal of medicinal chemistry, 2020
Amanda Garrido, Alban Lepailleur, S. Mignani, P. Dallemagne, Christophe Rochais   +4 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Nature Biotechnology, 2015
Elvin Blanco, Haifa Shen, M. Ferrari
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sulfilimines: An Underexplored Bioisostere for Drug Design? [PDF]

J Med Chem
Arvidsson PI.
europepmc   +1 more source

Virtual screening through graphical-automatic drug design (iGEMDOCK) approach and post-screening analysis of propolis compounds’ complexes with KIFC1.

Muhammad Bilal Azmi (14519913), Simran Kumari (5628227), Sakina Aquil (21492547), Urooj Nizami (21492550), Arisha Sohail (21368142), Syed Danish Haseen Ahmed (14519922), Shamim Akhtar Qureshi (14157525)   +6 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Computational-aided drug design strategies for drug discovery and development against oral diseases. [PDF]

Front Pharmacol
Wu T, Jiang W.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Exploring the macrocyclic chemical space for heuristic drug design with deep learning models. [PDF]

Commun Chem
Hu F, Jia X, Liao W, Chen Z, Bi H, Ge H, Liu D, Zhang R, Hu Y, Mei W, Zhao Z, Zhang K, Zhu L, Diao Y, Li H.   +14 more
europepmc   +1 more source