Results 321 to 330 of about 2,956,994 (356)
Enhancing De Novo Drug Design across Multiple Therapeutic Targets with CVAE Generative Models. [PDF]
ACS OmegaRomanelli V +5 more
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NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction. [PDF]
J Am Chem SocSakurabayashi S +11 more
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A commentary on 'Current perspectives and trend of computer-aided drug design: a review and bibliometric analysis'. [PDF]
Int J SurgJiang J, Ye Y, Li F, Luo H, Wang W.
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Effects of pH on opioid receptor activation and implications for drug design. [PDF]
Biophys JStein C.
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Emergency Medicine Clinics of North America, 2021
In recent years, there has been an emergence of numerous novel drugs. Such toxicity may occur in both adolescents and adults. This article discusses the opioid epidemic and several emerging opioids, including buprenorphine, loperamide, fentanyl, fentanyl derivatives, and others.
Michael Levine, Frank Lovecchio
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In recent years, there has been an emergence of numerous novel drugs. Such toxicity may occur in both adolescents and adults. This article discusses the opioid epidemic and several emerging opioids, including buprenorphine, loperamide, fentanyl, fentanyl derivatives, and others.
Michael Levine, Frank Lovecchio
openaire +2 more sources
Rational Drug Design Paradigms: The Odyssey for Designing Better Drugs
Combinatorial Chemistry & High Throughput Screening, 2015Due to the time and effort requirements for the development of a new drug, and the high attrition rates associated with this developmental process, there is an intense effort by academic and industrial researchers to find novel ways for more effective drug development schemes.
Kellici T +13 more
openaire +3 more sources
Current Pharmaceutical Design, 2003
The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.
Illana Gozes, Sharon Furman
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The following review outlines the physiological outcome of VIP and VIP gene manipulations. Previously, we reviewed the various VIP receptors associated with biological functions ranging from growth regulation, sexual function, bronchodilation, vasodilation and immune interactions to neurotrophism. VIP-based drug design is discussed below.
Illana Gozes, Sharon Furman
openaire +3 more sources
European Journal of Pharmacology, 2009
In this article, current knowledge of drug design is reviewed and an approach of rational drug design is presented. The process of drug development is challenging, expensive, and time consuming, although this process has been accelerated due to the development of computational tools and methodologies.
Meenal Moudgil +3 more
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In this article, current knowledge of drug design is reviewed and an approach of rational drug design is presented. The process of drug development is challenging, expensive, and time consuming, although this process has been accelerated due to the development of computational tools and methodologies.
Meenal Moudgil +3 more
openaire +3 more sources
Archives of Biochemistry and Biophysics, 2017
The use of NMR as a tool to determine 3 dimensional protein solution structures, once a darling of the pharmaceutical industry, has largely given way to study of the interaction of prospective drugs with macromolecular targets. Many of these approaches involve ligand-centered studies, which have the advantage of speed and efficiency, but there are also
Luciano Mueller +3 more
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The use of NMR as a tool to determine 3 dimensional protein solution structures, once a darling of the pharmaceutical industry, has largely given way to study of the interaction of prospective drugs with macromolecular targets. Many of these approaches involve ligand-centered studies, which have the advantage of speed and efficiency, but there are also
Luciano Mueller +3 more
openaire +3 more sources
Biochemical Pharmacology, 1975
Abstract Parachor has been used extensively in physical organic chemistry for structure determination. It has rarely been used as a parameter for the correlation of structure and biological activity. We have reexamined the parachor concept for structure-activity correlations of some closely related analogs.
Alan Mellors +2 more
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Abstract Parachor has been used extensively in physical organic chemistry for structure determination. It has rarely been used as a parameter for the correlation of structure and biological activity. We have reexamined the parachor concept for structure-activity correlations of some closely related analogs.
Alan Mellors +2 more
openaire +3 more sources