Results 131 to 140 of about 2,491,987 (318)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparative analysis of CDR3 length-dependent patterns in VHHs

Frontiers in Immunology
IntroductionVHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity ...
Lu Zhang, Tianyu Yang, Yao Zhang, Jiahui Yan, Jiaguo Li, Wenfeng Xu, Weimin Zhu, Xinhao Wang   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Essential oils enriched Dant-Kanti-Gandush (oil-pulling) inhibits inter-kingdom biofilm formation on orthodontic fixtures and ameliorates cariogenic virulence factors of oral pathogens

Scientific Reports
Orthodontic fixtures provide conducive niche for microbial colonization and inter-kingdom biofilm formation, exacerbating oral hygiene challenges. Conventional mouthwashes, though effective, are associated with adverse effects and potential antimicrobial
Acharya Balkrishna, Harshita Jonwal, Nem Kumar Ngpoore, Yash Varshney, Meenu Tomer, Monali Joshi, Kuldeep Singh, Pardeep Nain, Savita Lochab, Anurag Varshney   +9 more
doaj   +1 more source

Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits

Vaccines
Background: Respiratory syncytial virus (RSV) infections usually cause mild, cold-like symptoms in most people, but are a leading infectious disease causing infant death and hospitalization and can result in increased morbidity and mortality in older ...
Jun Zhou, Christopher J. Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily Gomme, Rani S. Sellers, Cynthia M. Rohde   +6 more
doaj   +1 more source

Pharmacokinetic studies for the development of transdermal drug delivery systems

, 2007
PhDThis thesis mainly describes a series of Phase I pharmacokinetic studies conducted on the TDS®d elivery systemw hich combinedw ith lidocaine,t estosteronea, nd a new drug, Melanotan-I for the transdermal drug delivery.
Chik, Zamri
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of knockdown approaches for the generation of stable cell populations expressing afucosylated antibodies

mAbs
Targeted silencing of cellular genes in cell lines stably expressing a secreted recombinant protein offers a flexible and convenient strategy for modulating product quality attributes.
Maria Tsachaki, Andrew Samy, Mégane Peltret, Timothee Brunstein Laplace, Emilie Vaxelaire-Hily, Farid Mosbaoui, Anna Galea, Francesca Contarin, Lionel Duarte, Roberto Giovannini, Martin Bertschinger   +10 more
doaj   +1 more source

Drug discovery and development for neglected diseases: the DNDi model

, 2011
Eric Chatelain, Jean-Robert IosetDrugs for Neglected Diseases Initiative (DNDi), Geneva, SwitzerlandAbstract: New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African
null Jean-Robert Ioset, null Chatelain, Jean-Robert Ioset, Eric Chatelain   +3 more
core   +1 more source