Results 151 to 160 of about 21,426,149 (319)

Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits

Vaccines
Background: Respiratory syncytial virus (RSV) infections usually cause mild, cold-like symptoms in most people, but are a leading infectious disease causing infant death and hospitalization and can result in increased morbidity and mortality in older ...
Jun Zhou, Christopher J. Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily Gomme, Rani S. Sellers, Cynthia M. Rohde   +6 more
doaj   +1 more source

The champions of drug development [PDF]

Nature Biotechnology, 2021
openaire   +2 more sources

IDB News: Vol. 2. no. 9, October 1975

, 1975
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Design, Synthesis, and Computational Evaluation of 3,4-Dihydroquinolin-2(1H)-One Analogues as Potential VEGFR2 Inhibitors in Glioblastoma Multiforme

Pharmaceuticals
Background/Objectives: Glioblastoma multiforme (GBM), an aggressive and deadly brain tumour, presents significant challenges in achieving effective treatment due to its resistance to current therapies and poor prognosis.
Shafeek Buhlak, Nadeem Abad, Jihane Akachar, Sana Saffour, Yunus Kesgun, Sevval Dik, Betul Yasin, Gizem Bati-Ayaz, Essam Hanashalshahaby, Hasan Türkez, Adil Mardinoglu   +10 more
doaj   +1 more source

Multi-level complexities in technological development: Competing strategies for drug discovery [PDF]

, 2009
Drug development regularly has to deal with complex circumstances on two levels: the local level of pharmacological intervention on specific target proteins, and the systems level of the effects of pharmacological intervention on the organism.
Adam, Matthias
core  

IDB News: Vol. 2, no. 11, December 1975

, 1975
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Integrating computational simulation and high-throughput screening for the development of robust ultra-high concentration formulation of IgG1 antibody

mAbs
High-viscosity monoclonal antibody (mAb) formulations impede injection, complicate manufacturing, and may affect drug stability and patient outcomes. Nevertheless, these issues can be effectively mitigated through the judicious selection of appropriate ...
Chen Lyu, Shuyan Lu, Yiqiu Yin, Hongling Li, Dahui Xing, Yanjie Lu, Shujing Zheng, Qiuyu Zhang, Lingyu Gao, Shuxian Xu, Qian Zou, Feng Liu, Jinliang Zhang, Yun Kang   +13 more
doaj   +1 more source

IDB News: Vol. 3, no. 4, May 1976

, 1976
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source